Document Detail


Effects of bilateral stimulation of the subthalamic nucleus in patients with severe Parkinson's disease and motor fluctuations.
MedLine Citation:
PMID:  12210858     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We present the efficacy and side effects of bilateral deep brain stimulation (DBS) of the subthalamic nuclei (STN) performed with a more simplified surgical procedure than described by the Grenoble group. A consecutive series of 26 patients with advanced and levodopa-responsive Parkinson's disease and motor complications was evaluated using the Unified Parkinson's Disease Rating Scale (UPDRS) part I-VI, timed tests, and a patient diary for 2 days concerning on-off phenomenon and dyskinesias. At 3 months, evaluation of stimulation by the UPDRS motor score was performed in a double-blind manner and a significant improvement of 57% was found. The results 12 months after surgery off medication showed significant improvement in both UPDRS motor score and activities of daily living of 64% and, on medication, a significant reduction of 86% in duration of dyskinesias and 83% in duration of off-periods. Reduction in medication was less than for other groups, probably because we used smaller doses of levodopa before the operation. No serious side effects were encountered. When the patients are carefully selected and followed up, bilateral DBS of STN is a significant progress in treatment of advanced idiopathic Parkinson's disease with levodopa-induced motor complications.
Authors:
Karen Østergaard; Niels Sunde; Erik Dupont
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Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Movement disorders : official journal of the Movement Disorder Society     Volume:  17     ISSN:  0885-3185     ISO Abbreviation:  Mov. Disord.     Publication Date:  2002 Jul 
Date Detail:
Created Date:  2002-09-04     Completed Date:  2002-11-20     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8610688     Medline TA:  Mov Disord     Country:  United States    
Other Details:
Languages:  eng     Pagination:  693-700     Citation Subset:  IM    
Copyright Information:
Copyright 2002 Movement Disorder Society
Affiliation:
Department of Neurology, Aarhus University Hospital, Aarhus, Denmark. karen.ostergaard@oncable.dk
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MeSH Terms
Descriptor/Qualifier:
Activities of Daily Living / classification
Adult
Aged
Antiparkinson Agents / administration & dosage,  adverse effects
Dominance, Cerebral / physiology*
Double-Blind Method
Electric Stimulation Therapy*
Electrodes, Implanted
Female
Follow-Up Studies
Humans
Levodopa / administration & dosage,  adverse effects
Male
Middle Aged
Neurologic Examination / drug effects
Parkinson Disease / physiopathology,  therapy*
Subthalamic Nucleus / physiopathology*
Chemical
Reg. No./Substance:
0/Antiparkinson Agents; 0/Levodopa

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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