Document Detail


Effects of the biguanide metformin on splanchnic blood flow in rats: preferential and dose-dependent increase in islet blood flow.
MedLine Citation:
PMID:  7568343     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The aim of the present study was to evaluate if metformin, a biguanide used in the treatment of noninsulin-dependent diabetes, induced any changes in splanchnic circulation. For this purpose, anesthetized rats were injected intraperitoneally with saline alone (1 ml/kg BW) or metformin (15 or 30 mg/kg BW) 30 min before blood flow measurements. No effects on blood glucose or serum insulin concentrations could be discerned after administration of metformin. Both duodenal, whole pancreatic and islet blood flow were approximately doubled by the lowest dose (15 mg/kg BW) metformin. However, the higher dose (30 mg/kg BW) did not affect duodenal or pancreatic blood flow, whereas islet blood flow was markedly increased also in this group of animals. It is concluded that the blood flow to the pancreatic islets can be specifically enhanced by metformin. To what extent this contributes to the antihyperglycemic action of the drug is presently unknown.
Authors:
L Jansson
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Pharmacology     Volume:  51     ISSN:  0031-7012     ISO Abbreviation:  Pharmacology     Publication Date:  1995 Jun 
Date Detail:
Created Date:  1995-11-09     Completed Date:  1995-11-09     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0152016     Medline TA:  Pharmacology     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  43-7     Citation Subset:  IM    
Affiliation:
Department of Medical Cell Biology, Uppsala University, Sweden.
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MeSH Terms
Descriptor/Qualifier:
Animals
Blood Glucose / drug effects
Dose-Response Relationship, Drug
Insulin / blood
Male
Metformin / pharmacology*
Pancreas / blood supply*,  drug effects
Rats
Rats, Sprague-Dawley
Splanchnic Circulation / drug effects*
Chemical
Reg. No./Substance:
0/Blood Glucose; 11061-68-0/Insulin; 657-24-9/Metformin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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