Document Detail

Effects of bigeminies and paired-pulse stimulation on oxygen consumption in dog left ventricle.
MedLine Citation:
PMID:  1694735     Owner:  NLM     Status:  MEDLINE    
In 10 excised, cross-circulated, isovolumically beating dog left ventricles, we examined the effects of bigeminy, including paired-pulse stimulation, on cardiac oxygen consumption (VO2) and evaluated whether the VO2 versus pressure-volume area (PVA) relation obtained from regularly beating hearts in our previous studies could account for the changes in VO2 during bigeminies with various coupling intervals. The extrasystolic interval (ESI) was decreased in four steps from 300 msec (regular rhythm) to paired-pulse stimulation (less than or equal to 210 msec). The sum of ESI and the postextrasystolic interval was always held constant (600 msec); therefore, the number of excitations was 200/min at any ESI. Both VO2 and PVA were measured in four runs: a small volume run at a ventricular volume of 13 ml, a large volume of 12 ml, a calcium run in which contractility was enhanced by CaCl2 at a small volume of 12 ml, and a verapamil run in which contractility was depressed by verapamil at a large volume of 20 ml. In any run, both VO2 and PVA were unchanged at long ESIs (greater than or equal to 250 msec) from each control value at regular rhythm, but VO2 markedly increased at short ESIs (less than or equal to 230 msec). VO2s during bigeminies with various ESIs were comparable with the theoretical VO2 values that were calculated by the VO2-PVA relation at regular rhythm. However, the theoretical VO2 values underestimated the measured VO2 values at the shortest ESIs under a high volume loading and in a high contractile state. This indicates that the PVA concept can be expanded to various arrhythmias unless ESI becomes very short.
T Nozawa; Y Yasumura; S Futaki; N Tanaka; H Suga
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Circulation research     Volume:  67     ISSN:  0009-7330     ISO Abbreviation:  Circ. Res.     Publication Date:  1990 Jul 
Date Detail:
Created Date:  1990-08-13     Completed Date:  1990-08-13     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0047103     Medline TA:  Circ Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  142-53     Citation Subset:  IM    
Department of Cardiovascular Dynamics, National Cardiovascular Center Research Institute, Osaka, Japan.
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MeSH Terms
Blood Pressure
Blood Volume
Calcium Chloride / pharmacology
Cardiac Complexes, Premature / physiopathology
Electric Stimulation* / methods
Heart / physiology*
Heart Ventricles
Hydrogen-Ion Concentration
Lactates / metabolism
Lactic Acid
Models, Cardiovascular
Myocardial Contraction
Myocardium / metabolism*
Oxygen Consumption*
Pulse / physiology*
Time Factors
Verapamil / pharmacology
Reg. No./Substance:
0/Lactates; 10043-52-4/Calcium Chloride; 50-21-5/Lactic Acid; 52-53-9/Verapamil

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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