Document Detail


Effects of betamethasone and thyroid releasing hormone on fetal lung maturation: an experimental and morphometric study.
MedLine Citation:
PMID:  15262347     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To determine the effects of betamethasone and thyroid releasing hormone (TRH) on morphologic fetal rabbit lung maturation when administered separately and in combination. MATERIAL AND METHODS: Twenty-five pregnant rabbits were divided into five groups. Study groups were as follows: TRH or betamethasone alone (between 24 and 27th days of gestation), TRH + betamethasone or betamethasone + TRH (second dose of drugs were added in the last 2 days), and the control. The pregnancies were terminated on the 27th day of gestation. Weights and volumes of the fetal lungs were determined and the results were compared. RESULTS: Mean lung weights in all treatment groups were significantly heavier than controls (P < 0.05). The differences between mean lung weights of TRH alone, TRH + betamethasone, and betamethasone alone groups were not statistically significant (P > 0.05), but the mean lung weight of betamethasone + TRH group was significantly lower than the other treatment groups (P < 0.05). Mean lung volume of TRH alone group was significantly higher than control group; however, there were no significant differences between other treatment groups and the control. No correlation was found between the lung weights and volumes in all groups (r = 0.1, P > 0.05). CONCLUSION: Only TRH alone treatment produced a significant increase in both fetal lung volume and weight compared to the control group. Administering TRH alone can lead to increased lung maturation. Combining TRH to corticosteroid treatment significantly decreased mean fetal lung weight, instead of an increase. According to these results combined used of these two substances probably counteract each others effect, instead of having a synergism.
Authors:
Ismail Mutafoglu; Sabahattin Altunyurt; Erbil Dogan; Berrin Acar; Meral Koyuncuoglu; Oktay Erten
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Publication Detail:
Type:  Evaluation Studies; Journal Article    
Journal Detail:
Title:  European journal of obstetrics, gynecology, and reproductive biology     Volume:  115     ISSN:  0301-2115     ISO Abbreviation:  Eur. J. Obstet. Gynecol. Reprod. Biol.     Publication Date:  2004 Aug 
Date Detail:
Created Date:  2004-07-20     Completed Date:  2004-12-09     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  0375672     Medline TA:  Eur J Obstet Gynecol Reprod Biol     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  154-8     Citation Subset:  IM    
Affiliation:
Dokuz Eylul University Faculty of Medicine Obstetrics; Gynecology, Inciralti, 35340, IZMIR, Turkey.
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MeSH Terms
Descriptor/Qualifier:
Animals
Betamethasone / pharmacology*
Drug Antagonism
Female
Fetal Organ Maturity / drug effects*
Glucocorticoids / pharmacology*
Hormones / pharmacology*
Lung / drug effects*,  embryology,  growth & development
Organ Size / drug effects
Pregnancy
Rabbits
Thyrotropin-Releasing Hormone / pharmacology*
Chemical
Reg. No./Substance:
0/Glucocorticoids; 0/Hormones; 24305-27-9/Thyrotropin-Releasing Hormone; 378-44-9/Betamethasone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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