Document Detail

Effects of beta-hydroxy-beta-methylbutyrate on muscle damage after a prolonged run.
MedLine Citation:
PMID:  11007567     Owner:  NLM     Status:  MEDLINE    
This study examined the effects of supplemental beta-hydroxy-beta-methylbutyrate (HMB) on muscle damage as a result of intense endurance exercise. Subjects (n = 13) were paired according to their 2-mile run times and past running experience. Each pair was randomly assigned a treatment of either HMB (3 g/day) or a placebo. After 6 wk of daily training and supplementation, all subjects participated in a prolonged run (20-km course). Creatine phosphokinase and lactate dehydrogenase (LDH) activities were measured before and after a prolonged run to assess muscle damage. The placebo-supplemented group exhibited a significantly greater (treatment main effect, P = 0.05) increase in creatine phosphokinase activity after a prolonged run than did the HMB-supplemented group. In addition, LDH activity was significantly lower (treatment main effect, P = 0.003) with HMB supplementation compared with the placebo-supplemented group. In conclusion, supplementation with 3.0 g of HMB results in a decreased creatine phosphokinase and LDH response after a prolonged run. These findings support the hypothesis that HMB supplementation helps prevent exercise-induced muscle damage.
A E Knitter; L Panton; J A Rathmacher; A Petersen; R Sharp
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  89     ISSN:  8750-7587     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  2000 Oct 
Date Detail:
Created Date:  2000-10-25     Completed Date:  2000-11-09     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1340-4     Citation Subset:  IM    
Human Performance Laboratory, Iowa State University, Ames, Iowa 50011, USA.
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MeSH Terms
Body Composition
Creatine Kinase / blood
Dietary Supplements
L-Lactate Dehydrogenase / blood
Middle Aged
Muscle, Skeletal / drug effects*,  physiology,  physiopathology
Oxygen Consumption / drug effects*
Running / physiology*
Valerates / administration & dosage,  blood,  pharmacology*
Reg. No./Substance:
0/Placebos; 0/Valerates; 3F752311CD/beta-hydroxyisovaleric acid; EC Dehydrogenase; EC Kinase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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