Document Detail

Effects of beta-endorphin on the contraction and electrical activity of the isolated perfused rat heart.
MedLine Citation:
PMID:  6097557     Owner:  NLM     Status:  MEDLINE    
beta-Endorphin at pharmacological doses reduced both the left ventricular systolic and diastolic pressures of the isolated rat heart. The reduction in the diastolic ventricular pressure was does dependent. Beta-Endorphin also altered the electrical activities of the isolated heart, disturbing the normal electrocardiogram pattern. The degree of disturbance was also dose dependent. Naloxone itself did not produce any effect. However it antagonized the depressant effects and completely abolished the effect of beta-endorphin on the electrical activity of the heart, indicating that beta-endorphin acts via the naloxone sensitive receptors. The results suggest a possible regulatory role of intracardiac endogenous opioid peptides in the cardiac functions.
A Y Lee; C Y Zhan; T M Wong
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  International journal of peptide and protein research     Volume:  24     ISSN:  0367-8377     ISO Abbreviation:  Int. J. Pept. Protein Res.     Publication Date:  1984 Nov 
Date Detail:
Created Date:  1985-02-27     Completed Date:  1985-02-27     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0330420     Medline TA:  Int J Pept Protein Res     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  525-8     Citation Subset:  IM    
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MeSH Terms
Action Potentials / drug effects
Blood Pressure / drug effects
Endorphins / pharmacology*
Heart / drug effects*,  physiology
Myocardial Contraction / drug effects*
Rats, Inbred Strains
Reg. No./Substance:
0/Endorphins; 60617-12-1/beta-Endorphin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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