| Effects of beta-blockers and nicardipine on oxotremorine-induced tremor in common marmosets. | |
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MedLine Citation:
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PMID: 10591485 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Effects of beta-blockers (propranolol, arotinolol and nipradilol) and a Ca2+ channel blocker (nicardipine) on oxotremorine-induced tremor were studied in common marmosets. Generalized tremor was elicited by an intraperitoneal administration of 0.25 mg/kg oxotremorine. Intensity of the tremor was classified into 7 degrees, and it was evaluated every 10 min. The total intensity of oxotremorine-induced tremor for each drug was expressed as "points", which were the sum of tremor intensity scores evaluated every 10 min up to 190 min following the administration of oxotremorine. Beta-blockers significantly suppressed the tremor. On the other hand, the Ca2+ channel blocker exacerbated the tremor. |
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Authors:
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M Mitsuda; M Nomoto; S Iwata |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Japanese journal of pharmacology Volume: 81 ISSN: 0021-5198 ISO Abbreviation: Jpn. J. Pharmacol. Publication Date: 1999 Oct |
Date Detail:
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Created Date: 2000-02-03 Completed Date: 2000-02-03 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 2983305R Medline TA: Jpn J Pharmacol Country: JAPAN |
Other Details:
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Languages: eng Pagination: 244-6 Citation Subset: IM |
Affiliation:
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Department of Pharmacology, Faculty of Medicine, Kagoshima University, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adrenergic beta-Antagonists
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pharmacology* Animals Calcium Channel Blockers / pharmacology* Callithrix Flunarizine / pharmacology Injections, Intraperitoneal Male Muscarinic Agonists* / administration & dosage Nicardipine / pharmacology* Nimodipine / pharmacology Oxotremorine* / administration & dosage Tremor / chemically induced, prevention & control* |
| Chemical | |
Reg. No./Substance:
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0/Adrenergic beta-Antagonists; 0/Calcium Channel Blockers; 0/Muscarinic Agonists; 52468-60-7/Flunarizine; 55985-32-5/Nicardipine; 66085-59-4/Nimodipine; 70-22-4/Oxotremorine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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