| Effects of beta-blocker therapy on ventilatory responses to exercise in patients with heart failure. | |
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MedLine Citation:
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PMID: 15948082 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Ventilatory efficiency is the increase in ventilation relative to carbon dioxide production during exercise. Congestive heart failure (CHF) is associated with decreased ventilatory efficiency. beta-blockers improve hemodynamics, prolong survival, and improve functional class in patients with CHF, though peak exercise performance may not improve. We hypothesized beta-blockers increase ventilatory efficiency in patients with CHF. METHODS AND RESULTS: The study group comprised 614 subjects with left ventricular ejection fraction < or = 40% referred for cardiopulmonary exercise testing. Clinical and exercise data were reviewed and recorded. For comparison, subjects were divided into those treated with beta-blockers (n = 195) and those not treated (n = 419). Subjects on beta-blockers had lower minute ventilation (12 +/- 4 versus 14 +/- 4 L/min, P < .001) at rest, which remained lower during submaximal and maximal exercise, by 4 and 6 L/min, respectively (P = .001). Ventilatory efficiency was increased in subjects treated with beta-blockers at submaximal (32 +/- 6 versus 34 +/- 7, P = .002) and maximal (34 +/- 7 versus 37 +/- 10, P = .005) exercise. Differences between treatment subgroups remained significant by covariate analysis; beta-blockers were also independently associated with decreased minute ventilation by multiple regression. CONCLUSION: Beta-blockers may be associated with increased ventilatory efficiency in CHF patients, which may contribute to improved functional class and quality of life. |
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Authors:
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Robert Wolk; Bruce D Johnson; Virend K Somers; Thomas G Allison; Ray W Squires; Gerald T Gau; Lyle J Olson |
Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Journal of cardiac failure Volume: 11 ISSN: 1071-9164 ISO Abbreviation: J. Card. Fail. Publication Date: 2005 Jun |
Date Detail:
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Created Date: 2005-06-10 Completed Date: 2005-11-14 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9442138 Medline TA: J Card Fail Country: United States |
Other Details:
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Languages: eng Pagination: 333-9 Citation Subset: IM |
Affiliation:
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Division of Cardiovascular Diseases, Department of Internal Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adrenergic beta-Antagonists
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therapeutic use* Carbazoles / therapeutic use Exercise Test Exercise Tolerance / drug effects* Female Follow-Up Studies Heart Failure / drug therapy*, physiopathology Humans Male Metoprolol / therapeutic use Middle Aged Propanolamines / therapeutic use Pulmonary Ventilation / drug effects* Quality of Life Respiratory Function Tests Retrospective Studies Treatment Outcome Ventricular Function, Left / drug effects |
| Grant Support | |
ID/Acronym/Agency:
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HL61560/HL/NHLBI NIH HHS; HL65176/HL/NHLBI NIH HHS; HL71478/HL/NHLBI NIH HHS; M01-RR00585/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Adrenergic beta-Antagonists; 0/Carbazoles; 0/Propanolamines; 37350-58-6/Metoprolol; 72956-09-3/carvedilol |
| Comments/Corrections | |
Comment In:
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J Card Fail. 2005 Jun;11(5):340-2
[PMID:
15948083
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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