| Effects of beta-blocker on left ventricular remodeling in rats with volume overload cardiac failure. | |
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MedLine Citation:
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PMID: 19057143 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The beneficial effects of beta-blockers on left ventricular (LV) remodeling have been reported in association with several conditions that cause heart failure, but their effects on the volume overloaded heart failure have not been well defined. Fifty Wistar rats that survived aortocaval (AC) shunt creation were randomly allotted into the following two groups: untreated animals (ACS; n=26) and animals treated with 100 mg/kg/day metoprolol (MP; ACS+MP; n=24). The effects of MP were evaluated at 1, 4 and 12 weeks post-surgery through echocardiographic, hemodynamic and pathologic studies. At 12 weeks post-surgery, LV wall thinning associated with chamber dilatation was observed in ACS but not in ACS+MP. LV end-diastolic pressure and diastolic wall stress were lower in ACS+MP than in ACS. The increase in LV weight was similar in both ACS and ACS+MP at 1 and 4 weeks post-surgery, but at 12 weeks post-surgery, it was significantly greater in ACS+MP than in ACS. At the cellular level, although the cardiac myocyte length progressively increased to a similar extent in both groups, the mean cross-sectional diameter of these cells in ACS+MP was greater than in ACS. In conclusion, MP did not prevent early eccentric hypertrophy in response to volume overload. However, in the late phase of volume overload-induced heart failure, MP appears to allow for myocyte cross-sectional growth and thus prevents LV wall thinning, resulting in a net increase in LV mass. In this manner, MP might contribute to reduction of diastolic wall stress and thereby delay progression of heart failure. |
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Authors:
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Masayuki Kobayashi; Noboru Machida; Ryou Tanaka; Yoshihisa Yamane |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Journal of veterinary medical science / the Japanese Society of Veterinary Science Volume: 70 ISSN: 0916-7250 ISO Abbreviation: J. Vet. Med. Sci. Publication Date: 2008 Nov |
Date Detail:
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Created Date: 2008-12-05 Completed Date: 2008-12-31 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9105360 Medline TA: J Vet Med Sci Country: Japan |
Other Details:
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Languages: eng Pagination: 1231-7 Citation Subset: IM |
Affiliation:
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Department of Veterinary Clinical Oncology, Faculty of Agriculture, Tokyo University of Agriculture and Technology, Tokyo, Japan. k-masa@cc.tuat.ac.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adrenergic beta-Antagonists
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therapeutic use* Animals Echocardiography, Transesophageal Heart Bypass, Right Heart Failure / prevention & control*, surgery Heart Ventricles / drug effects* Hemodynamics / drug effects, physiology Metoprolol / therapeutic use Muscle Cells / drug effects, physiology Rats Ventricular Dysfunction, Left / prevention & control, surgery Ventricular Function, Left / drug effects, physiology |
| Chemical | |
Reg. No./Substance:
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0/Adrenergic beta-Antagonists; 37350-58-6/Metoprolol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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