Document Detail


Effects of beta-amyloid (25-35) on learning in the common snail.
MedLine Citation:
PMID:  18401730     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effects of neurotoxic beta-amyloid fragment (25-35) on the formation of behavioral sensitization and a conditioned defensive reflex to food were studied. Administration of beta-amyloid (25-35) to common snails before the start of training led to a significant reduction in sensitization of the defensive reaction, weakening of the formation of the conditioned defensive reflex to food, and impairment of memory. These impairments to behavioral plasticity may be mediated by changes in synaptic plasticity previously observed in the presence of beta-amyloid.
Authors:
T A Korshunova; E I Samarova; N I Bravarenko; P M Balaban
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Neuroscience and behavioral physiology     Volume:  38     ISSN:  0097-0549     ISO Abbreviation:  Neurosci. Behav. Physiol.     Publication Date:  2008 May 
Date Detail:
Created Date:  2008-04-10     Completed Date:  2008-07-24     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0330471     Medline TA:  Neurosci Behav Physiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  377-82     Citation Subset:  IM    
Affiliation:
Laboratory for the Cellular Neurobiology of Learning, Institute of Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences, Moscow.
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MeSH Terms
Descriptor/Qualifier:
Amyloid beta-Protein / metabolism*
Animals
Association Learning / physiology*
Conditioning, Classical / physiology*
Helix (Snails) / metabolism*
Peptide Fragments / metabolism*
Reflex / physiology
Retention (Psychology) / physiology
Chemical
Reg. No./Substance:
0/Amyloid beta-Protein; 0/Peptide Fragments; 0/amyloid beta-protein (25-35)

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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