Document Detail

Effects of beta-alanine supplementation on the onset of neuromuscular fatigue and ventilatory threshold in women.
MedLine Citation:
PMID:  17136505     Owner:  NLM     Status:  MEDLINE    
This study examined the effects of 28 days of beta-alanine supplementation on the physical working capacity at fatigue threshold (PWCFT), ventilatory threshold (VT), maximal oxygen consumption (VO2-MAX), and time-to-exhaustion (TTE) in women. Twenty-two women (age+/-SD 27.4+/-6.1 yrs) participated and were randomly assigned to either the beta-alanine (CarnoSyn) or Placebo (PL) group. Before (pre) and after (post) the supplementation period, participants performed a continuous, incremental cycle ergometry test to exhaustion to determine the PWCFT, VT, VO2-MAX, and TTE. There was a 13.9, 12.6 and 2.5% increase (p<0.05) in VT, PWCFT, and TTE, respectively, for the beta-alanine group, with no changes in the PL (p>0.05). There were no changes for VO2-MAX (p>0.05) in either group. Results of this study indicate that beta-alanine supplementation delays the onset of neuromuscular fatigue (PWCFT) and the ventilatory threshold (VT) at submaximal workloads, and increase in TTE during maximal cycle ergometry performance. However, beta-alanine supplementation did not affect maximal aerobic power (VO2-MAX). In conclusion, beta-alanine supplementation appears to improve submaximal cycle ergometry performance and TTE in young women, perhaps as a result of an increased buffering capacity due to elevated muscle carnosine concentrations.
J R Stout; J T Cramer; R F Zoeller; D Torok; P Costa; J R Hoffman; R C Harris; J O'Kroy
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial     Date:  2006-11-30
Journal Detail:
Title:  Amino acids     Volume:  32     ISSN:  0939-4451     ISO Abbreviation:  Amino Acids     Publication Date:  2007  
Date Detail:
Created Date:  2007-04-09     Completed Date:  2007-09-14     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9200312     Medline TA:  Amino Acids     Country:  Austria    
Other Details:
Languages:  eng     Pagination:  381-6     Citation Subset:  IM    
Department of Health and Exercise Science, University of Oklahoma, Norman, OK 73019-6081, USA.
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MeSH Terms
Carnitine / metabolism
Dietary Supplements*
Mental Fatigue / metabolism,  prevention & control*
Muscle Fatigue / drug effects*
Muscle, Skeletal / metabolism
Oxygen Consumption / drug effects*
Physical Endurance / drug effects*
beta-Alanine / administration & dosage*
Reg. No./Substance:
107-95-9/beta-Alanine; 541-15-1/Carnitine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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