Document Detail

Effects of beta-adrenoreceptor blockade during chronic exercise on contextual fear conditioning and mRNA for galanin and brain-derived neurotrophic factor.
MedLine Citation:
PMID:  15598146     Owner:  NLM     Status:  MEDLINE    
The authors examined the effects of activity wheel running (AWR) and propranolol on contextual fear conditioning (CFC) and messenger RNA (mRNA) for galanin (GAL) in the locus coeruleus (LC) and brain-derived neurotrophic factor (BDNF) in the hippocampal formation (HF) in rats. Freezing behavior during the testing session of the CFC protocol was elevated in the AWR-placebo group compared to sedentary-placebo and AWR-propranolol groups. AWR increased GAL mRNA in the LC. CFC increased BDNF mRNA in the HF. These results suggest that exercise enhances CFC and that antagonism of the beta-adrenoreceptors attenuates this effect. The exercise-related induction of GAL gene expression in the LC may influence noradrenergic transmission to facilitate CFC.
Jacqueline D Van Hoomissen; Philip V Holmes; Andrew S Zellner; Adeline Poudevigne; Rod K Dishman
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Behavioral neuroscience     Volume:  118     ISSN:  0735-7044     ISO Abbreviation:  Behav. Neurosci.     Publication Date:  2004 Dec 
Date Detail:
Created Date:  2004-12-15     Completed Date:  2005-02-14     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8302411     Medline TA:  Behav Neurosci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1378-90     Citation Subset:  IM    
Department of Excercise Science, University of Georgia, USA.
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MeSH Terms
Adrenergic beta-Antagonists / pharmacology*
Analysis of Variance
Autoradiography / methods
Behavior, Animal
Brain-Derived Neurotrophic Factor / genetics,  metabolism*
Conditioning (Psychology) / drug effects*
Corticosterone / blood
Electroshock / adverse effects
Freezing Reaction, Cataleptic / drug effects
Galanin / genetics,  metabolism*
Gene Expression Regulation / drug effects
In Situ Hybridization / methods
Motor Activity / drug effects
Propranolol / pharmacology*
RNA, Messenger / metabolism
Radioimmunoassay / methods
Rats, Long-Evans
Time Factors
Reg. No./Substance:
0/Adrenergic beta-Antagonists; 0/Brain-Derived Neurotrophic Factor; 0/RNA, Messenger; 50-22-6/Corticosterone; 525-66-6/Propranolol; 88813-36-9/Galanin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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