| Effects of beta-adrenergic blockade on ventilation and gas exchange during exercise in humans. | |
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MedLine Citation:
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PMID: 6305897 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effects of beta-adrenergic blockade induced by intravenous propranolol hydrochloride (0.2 mg/kg) on ventilatory and gas exchange responses to exercise were studied during tests in which the work rate was either increased progressively or maintained at a constant load in six healthy young male subjects. Heart rate during exercise decreased by about 20% and cardiac output, as estimated by a modification of the method of Kim et al. (J. Appl. Physiol. 21: 1338-1344, 1966), by about 15%. The relation between work rate and O2 uptake (VO2) was unaffected by propranolol, whereas maximal O2 uptake (VO2max) decreased by 5% and the anaerobic threshold, estimated noninvasively, was lowered by 23%. The relations between CO2 output (VCO2) and end-tidal CO2 partial pressure (PCO2) and between VCO2 and minute ventilation (VE) were both unaffected. The time constants for changes of VO2, VCO2, and VE during on-transients from unloaded pedaling to either a moderate (ca. 50% VO2max) or a heavy (ca. 67% VO2max) work rate in the control studies were in agreement with previously reported values, i.e., 42, 60, and 69 s, respectively. beta-Blockade was associated with a significantly increased time constant for VO2 of 61 s but with less consistent and insignificant changes for VCO2 and VE. There was a small but significant increase of the time constant for heart rate from 40 to 45 s. It is concluded that propranolol exerts its primary influence during exercise on the cardiovascular system without any discernible effect on ventilatory control. |
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Authors:
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E S Petersen; B J Whipp; J A Davis; D J Huntsman; H V Brown; K Wasserman |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Journal of applied physiology: respiratory, environmental and exercise physiology Volume: 54 ISSN: 0161-7567 ISO Abbreviation: J Appl Physiol Publication Date: 1983 May |
Date Detail:
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Created Date: 1983-08-11 Completed Date: 1983-08-11 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 7801242 Medline TA: J Appl Physiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1306-13 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Anaerobiosis Cardiac Output / drug effects Exercise Test Heart Rate / drug effects Humans Kinetics Male Propranolol / pharmacology* Pulmonary Gas Exchange / drug effects* Receptors, Adrenergic / physiology* Receptors, Adrenergic, beta / physiology* |
| Grant Support | |
ID/Acronym/Agency:
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HL-11907/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Receptors, Adrenergic; 0/Receptors, Adrenergic, beta; 525-66-6/Propranolol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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