| Effects of the beta 2-adrenoceptor antagonist ICI 118,551 on blood pressure in hypertensive patients known to respond to beta 1-adrenoceptor antagonists. | |
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MedLine Citation:
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PMID: 2898256 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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1. The selective beta 2-adrenoceptor antagonist ICI 118,551, 50 mg orally given thrice daily, did not lower blood pressure in hypertensive patients known to respond to therapy with atenolol or propranolol. 2. This dosage regimen resulted in a small decrease in supine heart rate which might represent partial beta 1-adrenoceptor antagonism by ICI 118,551. 3. The results suggest that beta 2-selective antagonism does not play a role in the hypotensive action of beta-adrenoceptor antagonists. |
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Authors:
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O J Robb; J Webster; J C Petrie; J D Harry; J Young |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: British journal of clinical pharmacology Volume: 25 ISSN: 0306-5251 ISO Abbreviation: Br J Clin Pharmacol Publication Date: 1988 Apr |
Date Detail:
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Created Date: 1988-07-29 Completed Date: 1988-07-29 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 7503323 Medline TA: Br J Clin Pharmacol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 433-8 Citation Subset: IM |
Affiliation:
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Department of Medicine and Therapeutics, University of Aberdeen, Foresterhill. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adrenergic beta-Antagonists
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therapeutic use* Blood Pressure / drug effects* Female Heart Rate / drug effects Humans Hypertension / drug therapy*, physiopathology Male Middle Aged Propanolamines / therapeutic use* |
| Chemical | |
Reg. No./Substance:
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0/Adrenergic beta-Antagonists; 0/Propanolamines; 72795-19-8/ICI 118551 |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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