Document Detail

Effects of benzyl glucoside and chlorogenic acid from Prunus mume on adrenocorticotropic hormone (ACTH) and catecholamine levels in plasma of experimental menopausal model rats.
MedLine Citation:
PMID:  14709918     Owner:  NLM     Status:  MEDLINE    
To investigate the effectiveness of benzyl beta-D-glucopyranoside (BG) and chlorogenic acid (CA), the constituents of the fruit of Prunus mume, for relieving tension in experimental menopausal model rats (M-rats) caused by ether stress, the effects of BG and CA on adrenocorticotropic hormone (ACTH) and catecholamine (adrenaline, noradrenaline, and dopamine) levels were examined in the plasma of M-rats. Caffeic acid, quinic acid, and rosmarinic acid, which are compounds structurally related to CA, were also examined. BG obviously recovered catecholamine levels decreased by ether stress and increased dopamine to high levels. On the other hand, CA significantly decreased the ACTH level increased by ether stress and showed the greatest effect of all compounds. These results suggest that BG and CA may contribute to relieving the tension in M-rats caused by ether stress.
Hiroji Ina; Kenji Yamada; Kosai Matsumoto; Toshio Miyazaki
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Biological & pharmaceutical bulletin     Volume:  27     ISSN:  0918-6158     ISO Abbreviation:  Biol. Pharm. Bull.     Publication Date:  2004 Jan 
Date Detail:
Created Date:  2004-01-07     Completed Date:  2004-08-10     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9311984     Medline TA:  Biol Pharm Bull     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  136-7     Citation Subset:  IM    
School of Pharmacy, Tokyo University of Pharmacy and Life Science, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan.
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MeSH Terms
Adrenocorticotropic Hormone / blood*
Antioxidants / pharmacology
Caffeic Acids / pharmacology
Catecholamines / blood*
Chlorogenic Acid / isolation & purification,  pharmacology*
Cinnamates / pharmacology
Dose-Response Relationship, Drug
Fruit / chemistry
Glucosides / isolation & purification,  pharmacology*
Prunus / chemistry*
Quinic Acid / pharmacology
Sexual Maturation / physiology
Stress, Psychological / metabolism
Reg. No./Substance:
0/Antioxidants; 0/Caffeic Acids; 0/Catecholamines; 0/Cinnamates; 0/Depsides; 0/Glucosides; 327-97-9/Chlorogenic Acid; 331-39-5/caffeic acid; 4304-12-5/benzyl glucopyranoside; 537-15-5/rosmarinic acid; 77-95-2/Quinic Acid; 9002-60-2/Adrenocorticotropic Hormone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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