| Effects of benzyl glucoside and chlorogenic acid from Prunus mume on adrenocorticotropic hormone (ACTH) and catecholamine levels in plasma of experimental menopausal model rats. | |
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MedLine Citation:
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PMID: 14709918 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To investigate the effectiveness of benzyl beta-D-glucopyranoside (BG) and chlorogenic acid (CA), the constituents of the fruit of Prunus mume, for relieving tension in experimental menopausal model rats (M-rats) caused by ether stress, the effects of BG and CA on adrenocorticotropic hormone (ACTH) and catecholamine (adrenaline, noradrenaline, and dopamine) levels were examined in the plasma of M-rats. Caffeic acid, quinic acid, and rosmarinic acid, which are compounds structurally related to CA, were also examined. BG obviously recovered catecholamine levels decreased by ether stress and increased dopamine to high levels. On the other hand, CA significantly decreased the ACTH level increased by ether stress and showed the greatest effect of all compounds. These results suggest that BG and CA may contribute to relieving the tension in M-rats caused by ether stress. |
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Authors:
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Hiroji Ina; Kenji Yamada; Kosai Matsumoto; Toshio Miyazaki |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Biological & pharmaceutical bulletin Volume: 27 ISSN: 0918-6158 ISO Abbreviation: Biol. Pharm. Bull. Publication Date: 2004 Jan |
Date Detail:
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Created Date: 2004-01-07 Completed Date: 2004-08-10 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9311984 Medline TA: Biol Pharm Bull Country: Japan |
Other Details:
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Languages: eng Pagination: 136-7 Citation Subset: IM |
Affiliation:
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School of Pharmacy, Tokyo University of Pharmacy and Life Science, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan. inah@ps.toyaku.ac.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adrenocorticotropic Hormone
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blood* Animals Antioxidants / pharmacology Caffeic Acids / pharmacology Catecholamines / blood* Chlorogenic Acid / isolation & purification, pharmacology* Cinnamates / pharmacology Depsides Dose-Response Relationship, Drug Female Fruit / chemistry Glucosides / isolation & purification, pharmacology* Ovariectomy* Prunus / chemistry* Quinic Acid / pharmacology Rats Sexual Maturation / physiology Stress, Psychological / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Antioxidants; 0/Caffeic Acids; 0/Catecholamines; 0/Cinnamates; 0/Depsides; 0/Glucosides; 327-97-9/Chlorogenic Acid; 331-39-5/caffeic acid; 4304-12-5/benzyl glucopyranoside; 537-15-5/rosmarinic acid; 77-95-2/Quinic Acid; 9002-60-2/Adrenocorticotropic Hormone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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