Document Detail

Effects of benzo[a]pyrene on autonomic nervous system of coke oven workers.
MedLine Citation:
PMID:  18490851     Owner:  NLM     Status:  MEDLINE    
Objectives are to investigate the effects of benzo[a]pyrene (B[a]P) on the autonomic nervous system of coke oven workers. One hundred eighty-four coke oven workers were divided into 3 groups according to their working sites (coke oven bottom group, coke oven side group and coke oven top group), and 93 referents were recruited. B[a]P monitored by air sampling pumps as well as urinary 1-hydroxypyrene (1-OH-Py) was determined by high performance liquid chromatograph with a fluorescence detector (HPLC-FD). The autonomic nervous system (ANS) function was determined by 4 tests: Valsalva Manoeuvre heart rate variation (HR-V), variation of heart rate when breathing deeply (HR-DB), variation of heart rate when instantly standing up (HR-IS, including RR30:15 and RRmax:min) and variation of blood pressure when instantly standing up (BP-IS). The B[a]P mean concentrations in coke oven bottom, coke oven side and coke oven top were 19, 185 and 1,623 ng/m(3), respectively. The levels of urinary 1-OH-Py were markedly higher in the 3 exposed groups than that in the referent group (p<0.01). No significant difference was found in each group between smokers and non-smokers (p>0.05). Compared with referents, HR-V decreased significantly in coke oven workers (p<0.01), representing modulation of parasympathetic nervous function. However, no statistical differences were found in HR-DB, RR30:15, RRmax:min and BP-IS between the exposed groups and the control group (p>0.05). HR-V decreased with the increment of 1-OH-Py (p<0.05), and results of multiple linear stepwise regression demonstrated that external exposure level and duration of education entered the HR-V model; age was a significant factor of HR-DB and RRmax:min, but no variable was involved in RR30:15 and BP-IS regression. Benzo[a]pyrene affects the autonomic nervous function of coke oven workers mainly by down-regulating the parasympathetic nervous function.
Hong-Mei Zhang; Ji-Sheng Nie; Fang Wang; Ying-Tao Shi; Ling Zhang; Andrea Antonucci; Hui-Jun Liu; Jing Wang; Jie Zhao; Qin-Li Zhang; Lin-Ping Wang; Jing Song; Cui-E Xue; Mario Di Gioacchino; Qiao Niu
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-05-16
Journal Detail:
Title:  Journal of occupational health     Volume:  50     ISSN:  1348-9585     ISO Abbreviation:  J Occup Health     Publication Date:  2008  
Date Detail:
Created Date:  2008-08-07     Completed Date:  2008-10-27     Revised Date:  2011-03-29    
Medline Journal Info:
Nlm Unique ID:  9616320     Medline TA:  J Occup Health     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  308-16     Citation Subset:  IM    
Department of Occupational Health, School of Public Health, Shanxi Medical University, China.
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MeSH Terms
Autonomic Nervous System Diseases / chemically induced*
Benzo(a)pyrene / adverse effects*,  analysis
Middle Aged
Occupational Exposure / adverse effects*
Reg. No./Substance:
0/Coke; 50-32-8/Benzo(a)pyrene

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