Document Detail

Effects of benzamidine derivatives on Ha-ras-1 mRNA accumulation in a Chinese hamster cell line transformed with the activated human T24 Ha-ras-1 oncogene.
MedLine Citation:
PMID:  3284453     Owner:  NLM     Status:  MEDLINE    
Tetra benzamidine derivatives were found to inhibit proteinase activity, cell proliferation and accumulation of the Ha-ras-1 mRNA in the FHO6T1-1 Chinese Hamster cell line, transformed with the activated human T24-Ha-ras-1 oncogene. Di- and Tri-benzamidine derivatives were also found to be potent inhibitors of proliferation of FHO6T1-1 cells. These latter compounds could be proposed as useful substrates in the synthesis of drug-conjugated monoclonal antibodies or growth factors.
C Nastruzzi; G Feriotto; D Spandidos; D Anzanel; R Ferroni; M Guarneri; R Barbieri; R Gambari
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Anticancer research     Volume:  8     ISSN:  0250-7005     ISO Abbreviation:  Anticancer Res.     Publication Date:    1988 Mar-Apr
Date Detail:
Created Date:  1988-06-07     Completed Date:  1988-06-07     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8102988     Medline TA:  Anticancer Res     Country:  GREECE    
Other Details:
Languages:  eng     Pagination:  269-73     Citation Subset:  IM    
Dipartimento di Scienze Farmaceutiche, Universitá di Ferrara, Italy.
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MeSH Terms
Amidines / pharmacology*
Antibodies, Monoclonal
Benzamidines / pharmacology*
Cell Line / drug effects
Genes, ras*
Microscopy, Electron, Scanning
RNA, Messenger / metabolism*
Reg. No./Substance:
0/Amidines; 0/Antibodies, Monoclonal; 0/Benzamidines; 0/RNA, Messenger

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