| Effects of benidipine in a rat model for experimental angina. | |
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MedLine Citation:
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PMID: 17139163 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To compare the antianginal effects of 1,4-dihydropyridine-type calcium-channel blockers, we evaluated the effects of benidipine, amlodipine, nifedipine, and efonidipine on vasopressin-induced myocardial ischemia in rats, an experimental model of angina. Intravenous administration of benidipine (3 microg/kg), amlodipine (1000 microg/kg), and nifedipine (100 microg/kg) suppressed the vasopressin-induced S-wave depression, an index of myocardial ischemia. Efonidipine (100 microg/kg, i.v.) tended to inhibit the S-wave depression. At the antianginal dose of each drug, amlodipine, nifedipine, and efonidipine decreased blood pressure significantly, whereas benidipine had little effect on blood pressure at a dose of 3 microg/kg. These results indicate that benidipine, unlike the other 1,4-dihydropyridine-type calcium-channel blockers examined in this study, inhibits vasopressin-induced coronary vasospasm with fewer undesirable effects such as hypotension in rats, suggesting that benidipine may be useful in the treatment of angina pectoris. |
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Authors:
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Jun-ichi Ikeda; Masahiro Matsubara; Kozo Yao |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan Volume: 126 ISSN: 0031-6903 ISO Abbreviation: Yakugaku Zasshi Publication Date: 2006 Dec |
Date Detail:
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Created Date: 2006-12-01 Completed Date: 2007-02-07 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0413613 Medline TA: Yakugaku Zasshi Country: Japan |
Other Details:
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Languages: eng Pagination: 1377-81 Citation Subset: IM |
Affiliation:
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Department of Pharmacology and Molecular Biology, Pharmaceutical Research Center, Kyowa Hakko Kogyo Co., Ltd., Shizuoka, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Amlodipine
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adverse effects,
therapeutic use Angina Pectoris / drug therapy* Animals Blood Pressure / drug effects Calcium Channel Blockers / adverse effects, therapeutic use* Dihydropyridines / adverse effects, therapeutic use* Disease Models, Animal Male Nifedipine / adverse effects, therapeutic use Nitrophenols / adverse effects, therapeutic use Organophosphorus Compounds / adverse effects, therapeutic use Rats Rats, Inbred Strains |
| Chemical | |
Reg. No./Substance:
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0/Calcium Channel Blockers; 0/Dihydropyridines; 0/Nitrophenols; 0/Organophosphorus Compounds; 105979-17-7/benidipine; 111011-53-1/efonidipine; 21829-25-4/Nifedipine; 88150-42-9/Amlodipine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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