Document Detail


Effects of benidipine in a rat model for experimental angina.
MedLine Citation:
PMID:  17139163     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
To compare the antianginal effects of 1,4-dihydropyridine-type calcium-channel blockers, we evaluated the effects of benidipine, amlodipine, nifedipine, and efonidipine on vasopressin-induced myocardial ischemia in rats, an experimental model of angina. Intravenous administration of benidipine (3 microg/kg), amlodipine (1000 microg/kg), and nifedipine (100 microg/kg) suppressed the vasopressin-induced S-wave depression, an index of myocardial ischemia. Efonidipine (100 microg/kg, i.v.) tended to inhibit the S-wave depression. At the antianginal dose of each drug, amlodipine, nifedipine, and efonidipine decreased blood pressure significantly, whereas benidipine had little effect on blood pressure at a dose of 3 microg/kg. These results indicate that benidipine, unlike the other 1,4-dihydropyridine-type calcium-channel blockers examined in this study, inhibits vasopressin-induced coronary vasospasm with fewer undesirable effects such as hypotension in rats, suggesting that benidipine may be useful in the treatment of angina pectoris.
Authors:
Jun-ichi Ikeda; Masahiro Matsubara; Kozo Yao
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan     Volume:  126     ISSN:  0031-6903     ISO Abbreviation:  Yakugaku Zasshi     Publication Date:  2006 Dec 
Date Detail:
Created Date:  2006-12-01     Completed Date:  2007-02-07     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0413613     Medline TA:  Yakugaku Zasshi     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  1377-81     Citation Subset:  IM    
Affiliation:
Department of Pharmacology and Molecular Biology, Pharmaceutical Research Center, Kyowa Hakko Kogyo Co., Ltd., Shizuoka, Japan.
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MeSH Terms
Descriptor/Qualifier:
Amlodipine / adverse effects,  therapeutic use
Angina Pectoris / drug therapy*
Animals
Blood Pressure / drug effects
Calcium Channel Blockers / adverse effects,  therapeutic use*
Dihydropyridines / adverse effects,  therapeutic use*
Disease Models, Animal
Male
Nifedipine / adverse effects,  therapeutic use
Nitrophenols / adverse effects,  therapeutic use
Organophosphorus Compounds / adverse effects,  therapeutic use
Rats
Rats, Inbred Strains
Chemical
Reg. No./Substance:
0/Calcium Channel Blockers; 0/Dihydropyridines; 0/Nitrophenols; 0/Organophosphorus Compounds; 105979-17-7/benidipine; 111011-53-1/efonidipine; 21829-25-4/Nifedipine; 88150-42-9/Amlodipine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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