| Effects of benazepril on cardiac fibrosis in STZ-induced diabetic rats. | |
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MedLine Citation:
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PMID: 20821936 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: The present study was designed to explore the roles of MMP-2/TIMP-2 in cardiac fibrosis and to study the effects of benazepril, an angiotensin-converting enzyme inhibitor (ACEI) on cardiac remodelling in streptozotocin(STZ)-induced diabetic rats. METHODS AND RESULTS: Male Wistar rats were randomly divided into three groups: a normal control group (NC), a diabetes mellitus-untreated group (DM) and a diabetes mellitus benazepril-treated group (DB). Diabetes mellitus was induced in the DM and DB groups by intraperitoneal injection of streptozotocin (60 mg/kg). DB rats were treated with benazepril 10 mg/kg/day for 12 weeks by remedial perfusing of the stomach. In the DM group, compared with the NC group, the gene and protein expression of MMP-2 decreased while the TIMP-2 gene and protein expression increased in heart tissues, along with a markedly cardiac collagen deposition.All the above changes were attenuated by benazepril treatment in the DB group. CONCLUSIONS: The imbalance of MMP-2 and TIMP-2 expressions in heart tissues might participate in interstitial fibrosis in diabetic myocardiopathy. Benazepril may ameliorate cardiac fibrosis partly by regulating the MMP-2/TIMP-2 system. |
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Authors:
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Qian Li; Yi Wang; Shu-zhen Sun; Yong-jie Tian; Ming-hua Liu |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Acta cardiologica Volume: 65 ISSN: 0001-5385 ISO Abbreviation: Acta Cardiol Publication Date: 2010 Aug |
Date Detail:
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Created Date: 2010-09-08 Completed Date: 2010-11-02 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0370570 Medline TA: Acta Cardiol Country: Belgium |
Other Details:
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Languages: eng Pagination: 431-9 Citation Subset: IM |
Affiliation:
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Dept. of Pediatrics, Provincial Hospital Affiliated to Shandong University, Jinan 250021, China. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Analysis of Variance Angiotensin-Converting Enzyme Inhibitors / pharmacology* Animals Benzazepines / pharmacology* Blood Glucose / metabolism Body Weight Collagen / metabolism Diabetes Mellitus, Experimental / drug therapy* Fibrosis / drug therapy Immunoenzyme Techniques Male Matrix Metalloproteinase 2 / metabolism Myocardium / pathology* Organ Size Random Allocation Rats Rats, Wistar Reverse Transcriptase Polymerase Chain Reaction Staining and Labeling Streptozocin Tissue Inhibitor of Metalloproteinase-2 / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Angiotensin-Converting Enzyme Inhibitors; 0/Benzazepines; 0/Blood Glucose; 127497-59-0/Tissue Inhibitor of Metalloproteinase-2; 18883-66-4/Streptozocin; 86541-75-5/benazepril; 9007-34-5/Collagen; EC 3.4.24.24/Matrix Metalloproteinase 2 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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