Document Detail

Effects of a bacteriocin from Mycobacterium smegmatis on BALB/3T3 and simian virus 40-transformed BALB/c mouse cells.
MedLine Citation:
PMID:  6166835     Owner:  NLM     Status:  MEDLINE    
The effects of a bacteriocin from Mycobacterium smegmatis ATCC 14468 on simian virus 40-transformed BALB/c mouse cells (mKS-A TU-7 cells) and nontransformed BALB/3T3 cells originating from the BALB/c mouse strain were studied. The percentage of nigrosin-unstained (viable) cells in the bacteriocin-treated mKS-A TU-7 cells decreased time-dependently with an increase in the bacteriocin activity. There was a time-dependent decrease in the bacteriocin activity after treatment with the cell membrane preparation from mKS-A TU-7 cells. There was no apparent effect of the bacteriocin on the viability of nontransformed BALB/3T3 cells. Wheat germ agglutinin blocked the toxic effect of bacteriocin on mKS-A TU-7 cells. These results indicate that the higher sensitivity and binding capacity of the tumor cells to the bacteriocin is probably due to the presence of a large amount of N-acetyl-glucosamine or closely related sugar residues with a high affinity for bacteriocin, as compared with normal cells. The bacteriocin produced morphological alterations and inhibition of synthesis of ribonucleic acid, deoxyribonucleic acid and protein in the transformed but not in the nontransformed cells.
H Saito; T Watanabe
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Microbiology and immunology     Volume:  25     ISSN:  0385-5600     ISO Abbreviation:  Microbiol. Immunol.     Publication Date:  1981  
Date Detail:
Created Date:  1981-09-15     Completed Date:  1981-09-15     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7703966     Medline TA:  Microbiol Immunol     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  13-22     Citation Subset:  IM    
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MeSH Terms
Bacteriocins / pharmacology*
Cell Line
Cell Membrane / physiology
Cell Survival / drug effects*
Cell Transformation, Neoplastic*
Cell Transformation, Viral*
DNA / biosynthesis
Lectins / pharmacology
Mice, Inbred BALB C
Protein Biosynthesis
RNA / biosynthesis
Simian virus 40
Wheat Germ Agglutinins
Reg. No./Substance:
0/Bacteriocins; 0/Lectins; 0/Wheat Germ Agglutinins; 63231-63-0/RNA; 76012-58-3/smegmatocin; 9007-49-2/DNA

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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