| Effects of bacterial vaginosis and other genital infections on the natural history of human papillomavirus infection in HIV-1-infected and high-risk HIV-1-uninfected women. | |
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MedLine Citation:
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PMID: 15747249 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Whether the natural history of human papillomavirus (HPV) infection is affected by bacterial vaginosis (BV) or Trichomonas vaginalis (TV) infection has not been adequately investigated in prospective studies. METHODS: Human immunodeficiency virus 1 (HIV-1)-infected (n=1763) and high-risk HIV-1-uninfected (n=493) women were assessed semiannually for BV (by Nugent's criteria), TV infection (by wet mount), type-specific HPV (by polymerase chain reaction with MY09/MY11/HMB01 HPV primers), and squamous intraepithelial lesions (SIL) (by cytological examination). Sexual history was obtained from patient report at each visit. Risk factors for prevalent and incident HPV infection and SIL were evaluated by use of multivariate models. RESULTS: BV was associated with both prevalent and incident HPV infection but not with duration of HPV infection or incidence of SIL. TV infection was associated with incident HPV infection and with decreased duration and lower prevalence of HPV infection. TV infection had no association with development of SIL. Effects of BV and TV infection were similar in HIV-1-infected and high-risk HIV-1-uninfected women. HIV-1 infection and low CD4(+) lymphocyte count were strongly associated with HPV infection and development of SIL. CONCLUSIONS: BV and TV infection may increase the risk of acquisition (or reactivation) of HPV infection, as is consistent with hypotheses that the local cervicovaginal milieu plays a role in susceptibility to HPV infection. The finding that BV did not affect persistence of HPV infection and that TV infection may shorten the duration of HPV infection helps explain the lack of effect that BV and TV infection have on development of SIL. |
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Authors:
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D Heather Watts; Melissa Fazzari; Melissa Fazarri; Howard Minkoff; Sharon L Hillier; Beverly Sha; Marshall Glesby; Alexandra M Levine; Robert Burk; Joel M Palefsky; Michael Moxley; Linda Ahdieh-Grant; Howard D Strickler |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. Date: 2005-02-21 |
Journal Detail:
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Title: The Journal of infectious diseases Volume: 191 ISSN: 0022-1899 ISO Abbreviation: J. Infect. Dis. Publication Date: 2005 Apr |
Date Detail:
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Created Date: 2005-03-04 Completed Date: 2005-05-06 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0413675 Medline TA: J Infect Dis Country: United States |
Other Details:
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Languages: eng Pagination: 1129-39 Citation Subset: AIM; IM |
Affiliation:
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National Institute of Child Health and Human Development, NIH, Bethesda, Maryland 20892-7510, USA. hw59i@nih.gov |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult CD4 Lymphocyte Count Female HIV Infections / complications* Humans Middle Aged Neoplasms, Squamous Cell / epidemiology Papillomaviridae / isolation & purification Papillomavirus Infections / complications*, physiopathology* Prospective Studies Risk Factors Trichomonas Vaginitis / complications* United States Vagina / cytology, microbiology, parasitology, virology Vaginal Douching Vaginal Smears Vaginosis, Bacterial / complications* |
| Grant Support | |
ID/Acronym/Agency:
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M01 RR00079/RR/NCRR NIH HHS; N01-AI-35161/AI/NIAID NIH HHS; R01 CA85178-01/CA/NCI NIH HHS; U01-AI-31834/AI/NIAID NIH HHS; U01-AI-34989/AI/NIAID NIH HHS; U01-AI-34993/AI/NIAID NIH HHS; U01-AI-35004/AI/NIAID NIH HHS; U01-AI-42590/AI/NIAID NIH HHS; U01-AI34994/AI/NIAID NIH HHS; U01-HD-32632/HD/NICHD NIH HHS |
| Comments/Corrections | |
Erratum In:
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J Infect Dis. 2005 Sep 1;192(5):943 Note: Fazarri, Melissa [corrected to Fazzari, Melissa] |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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