| Effects of azithromycin on ozone-induced airway neutrophilia and cytokine release. | |
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MedLine Citation:
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PMID: 10853849 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Exposure of humans to ozone causes increased neutrophils and inflammatory cytokines in airway lining fluid. Recent research shows that macrolide antibiotics may reduce interleukin (IL)-8 production by bronchial epithelial cells and inhibit neutrophil chemotaxis. A double-blind, cross-over study was performed in which 12 healthy subjects underwent two separate 4-h exposures to 0.2 parts per million ozone while exercising intermittently. In the 73.5 h before exposure, subjects were pretreated with either 1,250 mg azithromycin or placebo. Sputum induction conducted 74 h pre- and 18 h post-exposure was used to measure total cells, per cent neutrophils, IL-6, and IL-8. There were significant (p<0.05) pre- to post-exposure increases in total cells, neutrophils, IL-6 and IL-8 in both the azithromycin and placebo arms. However, no significant differences were found between azithromycin and placebo conditions in the post- minus pre-exposure value for these variables. The results suggest that in healthy subjects, in the design used, azithromycin, in usual clinical doses, does not have anti-inflammatory effects on human airways as indicated in the measured variables. |
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Authors:
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G I Criqui; C Solomon; B S Welch; R E Ferrando; H A Boushey; J R Balmes |
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Publication Detail:
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Type: Clinical Trial; Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology Volume: 15 ISSN: 0903-1936 ISO Abbreviation: Eur. Respir. J. Publication Date: 2000 May |
Date Detail:
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Created Date: 2000-10-18 Completed Date: 2000-10-18 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 8803460 Medline TA: Eur Respir J Country: DENMARK |
Other Details:
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Languages: eng Pagination: 856-62 Citation Subset: IM |
Affiliation:
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Lung Biology Center, Dept of Medicine, University of California, San Francisco 94143-0854, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Anti-Bacterial Agents Azithromycin / pharmacology* Cross-Over Studies Double-Blind Method Female Humans Interleukin-6 / analysis, biosynthesis* Interleukin-8 / analysis, biosynthesis* Lung / physiology Male Neutrophils / drug effects* Ozone / pharmacology* Peroxidase / analysis, biosynthesis* Spirometry Sputum / chemistry*, cytology* |
| Grant Support | |
ID/Acronym/Agency:
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NIH/SCOR/P50HL56385/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Anti-Bacterial Agents; 0/Interleukin-6; 0/Interleukin-8; 10028-15-6/Ozone; 83905-01-5/Azithromycin; EC 1.11.1.7/Peroxidase |
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