Document Detail

Effects of azimilide, a KV(r) and KV(s) blocker, on canine ventricular arrhythmia models.
MedLine Citation:
PMID:  10440086     Owner:  NLM     Status:  MEDLINE    
Using canine coronary artery ligation/reperfusion and adrenaline arrhythmia models, we determined the effects of azimilide, a class III antiarrhythmic agent, E-1-[[(5-(4-chlorophenyl)-2-furanyl) methylene]-amino]-3-[4-(4-methyl-1-piperazinyl)butyl]-2,4-imidazolidi nedione dihydrochloride. The coronary ligation/reperfusion arrhythmia experiments were divided into two groups, one using low heart rate halothane-anesthetized and the other using high heart rate pentobarbital-anesthetized dogs. Azimilide (6 mg kg(-1) + 0.1 mg kg(-1) min(-1) i.v.) prolonged the corrected QT interval (QTc), decreased the heart rate and suppressed the premature ventricular complexes during ligation (35 +/- 17 beats/30 min as compared with 909 +/- 246 in the control group), and also suppressed ventricular fibrillation induced by coronary ligation/reperfusion in the two groups (1/8 halothane-anesthetized dogs as compared with 7/8 dogs in the control group and 2/8 pentobarbital-anesthetized dogs as compared with 8/8 dogs in the control group). In adrenaline arrhythmia, azimilide hastened the onset of adrenaline arrhythmias and also aggravated the arrhythmias, showing proarrhythmic effects.
Y Xue; C Yamada; D Chino; K Hashimoto
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  European journal of pharmacology     Volume:  376     ISSN:  0014-2999     ISO Abbreviation:  Eur. J. Pharmacol.     Publication Date:  1999 Jul 
Date Detail:
Created Date:  1999-09-27     Completed Date:  1999-09-27     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  1254354     Medline TA:  Eur J Pharmacol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  27-35     Citation Subset:  IM    
Department of Pharmacology, Yamanashi Medical University, Japan.
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MeSH Terms
Anti-Arrhythmia Agents / administration & dosage,  pharmacology*,  toxicity
Arrhythmias, Cardiac / etiology,  prevention & control*
Imidazoles / administration & dosage,  pharmacology*,  toxicity
Infusions, Intravenous
Injections, Intravenous
Myocardial Reperfusion Injury / complications
Piperazines / administration & dosage,  pharmacology*,  toxicity
Potassium Channel Blockers*
Ventricular Fibrillation / etiology,  prevention & control
Reg. No./Substance:
0/Anesthetics; 0/Anti-Arrhythmia Agents; 0/Imidazoles; 0/Imidazolidines; 0/Piperazines; 0/Potassium Channel Blockers; 149888-94-8/azimilide; 151-67-7/Halothane; 51-43-4/Epinephrine; 76-74-4/Pentobarbital

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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