| Effects of autonomic denervation on canine exocrine pancreatic secretion and blood flow. | |
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MedLine Citation:
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PMID: 3361158 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effect of autonomic denervation on the exocrine pancreatic secretion and blood flow was studied in a group of dogs. Pancreatic secretion was collected and analyzed for volume and bicarbonate by direct cannulation of the main papilla through a duodenotomy prior to and following truncal vagotomy and celiac plexus denervation. Pancreatic blood flow was determined by the radioisotope distribution method (141Ce). Truncal vagotomy causes a reduction in pancreatic secretion of volume and bicarbonate by 25-30%, while celiac denervation caused a reduction of 70% in the secretion. The mean baseline pancreatic blood flow was 0.5 ml/g pancreas/min. Truncal vagotomy did not cause any significant flow changes, while celiac denervation caused a significant increase in blood flow of 350% (to 1.75 ml/g/min). These results suggest that both the parasympathetic and the sympathetic system affect pancreatic secretion independently of their effect upon pancreatic blood flow. |
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Authors:
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E Klein; A Salinas; E Shemesh; D A Dreiling |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: International journal of pancreatology : official journal of the International Association of Pancreatology Volume: 3 ISSN: 0169-4197 ISO Abbreviation: Int. J. Pancreatol. Publication Date: 1988 Mar |
Date Detail:
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Created Date: 1988-05-31 Completed Date: 1988-05-31 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 8703511 Medline TA: Int J Pancreatol Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 165-70 Citation Subset: IM |
Affiliation:
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Department of Surgery, Chaim Sheba Medical Center, Tel-Hashomer, Israel. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Autonomic Nervous System / physiology* Denervation Dogs Pancreas / innervation*, physiology Pancreatic Juice / secretion* Regional Blood Flow Vagotomy |
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