Document Detail


Effects of autonomic denervation on canine exocrine pancreatic secretion and blood flow.
MedLine Citation:
PMID:  3361158     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effect of autonomic denervation on the exocrine pancreatic secretion and blood flow was studied in a group of dogs. Pancreatic secretion was collected and analyzed for volume and bicarbonate by direct cannulation of the main papilla through a duodenotomy prior to and following truncal vagotomy and celiac plexus denervation. Pancreatic blood flow was determined by the radioisotope distribution method (141Ce). Truncal vagotomy causes a reduction in pancreatic secretion of volume and bicarbonate by 25-30%, while celiac denervation caused a reduction of 70% in the secretion. The mean baseline pancreatic blood flow was 0.5 ml/g pancreas/min. Truncal vagotomy did not cause any significant flow changes, while celiac denervation caused a significant increase in blood flow of 350% (to 1.75 ml/g/min). These results suggest that both the parasympathetic and the sympathetic system affect pancreatic secretion independently of their effect upon pancreatic blood flow.
Authors:
E Klein; A Salinas; E Shemesh; D A Dreiling
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  International journal of pancreatology : official journal of the International Association of Pancreatology     Volume:  3     ISSN:  0169-4197     ISO Abbreviation:  Int. J. Pancreatol.     Publication Date:  1988 Mar 
Date Detail:
Created Date:  1988-05-31     Completed Date:  1988-05-31     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  8703511     Medline TA:  Int J Pancreatol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  165-70     Citation Subset:  IM    
Affiliation:
Department of Surgery, Chaim Sheba Medical Center, Tel-Hashomer, Israel.
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MeSH Terms
Descriptor/Qualifier:
Animals
Autonomic Nervous System / physiology*
Denervation
Dogs
Pancreas / innervation*,  physiology
Pancreatic Juice / secretion*
Regional Blood Flow
Vagotomy

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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