| Effects of autonomic blockade on non-linear cardiovascular variability indices in rats. | |
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MedLine Citation:
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PMID: 16700875 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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1. The present study assesses the effects of autonomic blockade (alpha- and beta-adrenoceptor and cholinergic) on cardiovascular function studied by heart rate variability (HRV), blood pressure variability (BPV) and baroreflex sensitivity in rats using non-linear dynamics. Little is known about the influence of pharmacological autonomic nervous system interventions on non-linear cardiovascular regulatory indices. 2. In 13 conscious rats, heart rate and aortic blood pressure were measured continuously before, during and after autonomic blockade with atropine, phentolamine and propranolol. Non-linear scaling properties were studied using 1/f slope, fractal dimension and long- and short-term correlation. Non-linear complexity was described with correlation dimension, Lyapunov exponent and approximate entropy. Non-linear indices were compared with linear time and frequency domain indices. 3. Beta-adrenoceptor blockade did not alter the non-linear characteristics of HRV and BPV, although low-frequency power of HRV was depressed. Alpha-adrenoceptor blockade decreased the scaling behaviour of HRV, whereas cholinergic blockade decreased the complexity of the non-linear system of HRV. For BPV, the scaling behaviour was increased during alpha-adrenoceptor blockade and the complexity was increased during cholinergic blockade. The linear indices of HRV and BPV were decreased. 4. The present results indicate that the beta-adrenoceptor system has little involvement in the generation of non-linear HRV and BPV in rats. 5. Alpha-adrenoceptor blockade mostly influenced the scaling properties of the time series, whereas cholinergic blockade induced changes in the complexity measures. 6. The absence of the baroreflex mechanism can trigger a compensatory feed-forward system increasing the complexity of BPV. |
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Authors:
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Frank Beckers; Bart Verheyden; Dirk Ramaekers; Bernard Swynghedauw; André E Aubert |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Clinical and experimental pharmacology & physiology Volume: 33 ISSN: 0305-1870 ISO Abbreviation: Clin. Exp. Pharmacol. Physiol. Publication Date: 2006 May-Jun |
Date Detail:
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Created Date: 2006-05-16 Completed Date: 2007-08-08 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0425076 Medline TA: Clin Exp Pharmacol Physiol Country: Australia |
Other Details:
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Languages: eng Pagination: 431-9 Citation Subset: IM |
Affiliation:
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Laboratory of Experimental Cardiology, School of Medicine, Gasthuisberg University Hospital, KU Leuven, Leuven, Belgium. andre.aubert@med.kuleuven.ac.be |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adrenergic alpha-Antagonists
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pharmacology* Adrenergic beta-Antagonists / pharmacology Animals Atropine / pharmacology Autonomic Nervous System / drug effects* Baroreflex* Blood Pressure Fractals Heart Rate Male Models, Cardiovascular Muscarinic Antagonists / pharmacology* Nonlinear Dynamics Phentolamine / pharmacology Propranolol / pharmacology Rats Rats, Wistar |
| Chemical | |
Reg. No./Substance:
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0/Adrenergic alpha-Antagonists; 0/Adrenergic beta-Antagonists; 0/Muscarinic Antagonists; 50-60-2/Phentolamine; 51-55-8/Atropine; 525-66-6/Propranolol |
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