Document Detail

Effects of atrioventricular intervals on right atrial monophasic action potential duration during pacing or reciprocating tachycardia.
MedLine Citation:
PMID:  7474360     Owner:  NLM     Status:  MEDLINE    
We evaluated the relationship between changes in the atrioventricular (AV) intervals and right atrial monophasic action potential duration at 90% repolarization (RA-MAPD90) in humans. In 4 patients, RA-MAPD90 was measured during AV reciprocating tachycardia (AVRT, n = 2) or AV node reentrant tachycardia (AVNRT, n = 2) and atrial or ventricular pacing at similar cycle lengths. In 10 patients, RA-MAPD90 was measured during continuous atrioventricular sequential pacing at AV intervals of 0, 50, 100, 150, 200, 250, 300, 350 msec for 90 sec at a cycle length of 333-400 msec. In patients with AVRT, the RA-MAPD90 during tachycardia was shorter than RA-MAPD90 during RA or RV pacing. In patients with AVNRT, RA-MAPD90 during tachycardia was similar or longer than RA-MAPD90 during RA or RV pacing. As the AV interval was increased from 0 msec to 150 msec, the peak right atrial pressure decreased from 8-12 mmHg to 2-3 mmHg. RA-MAPD90 decreased to its minimal value at an AV interval of 150 msec. The maximal difference in the RA-MAPD90 obtained by changing the AV interval was 22.5 +/- 3.0 msec. We conclude that 1) a very short AV or VA interval causes an increase in RA-MAPD90 which correlates with an increase in RA pressure, and 2) RA-MAPD90 during supraventricular tachycardia is different from RA-MAPD90 during atrial or ventricular pacing. Thus, a contraction-excitation feedback mechanism may exist in the human atrium.
A Kanda; I Watanabe; T Kojima; K Kondo; S Kunimoto; Y Takahashi; Y Kasamaki; T Ogura; J Kajita; S Saito
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Japanese heart journal     Volume:  36     ISSN:  0021-4868     ISO Abbreviation:  Jpn Heart J     Publication Date:  1995 Jul 
Date Detail:
Created Date:  1995-12-05     Completed Date:  1995-12-05     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0401175     Medline TA:  Jpn Heart J     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  439-50     Citation Subset:  IM    
Second Department of Internal Medicine, Nihon University School of Medicine, Tokyo, Japan.
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MeSH Terms
Action Potentials
Atrial Function, Right*
Atrioventricular Node / physiopathology*
Cardiac Pacing, Artificial*
Middle Aged
Myocardial Contraction
Reaction Time
Tachycardia, Supraventricular / physiopathology*

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