Document Detail

Effects of atriopeptin III on renal function, regional blood flows and left ventricular function in conscious dogs in presence or absence of hypovolaemia.
MedLine Citation:
PMID:  2951259     Owner:  NLM     Status:  MEDLINE    
The effects of atriopeptin III (AP III) on the left ventricular and renal functions were studied in thirteen chronically instrumented conscious dogs and compared to those of the solvent (saline). In the normovolaemic state, an AP III infusion (1 microgram kg-1 min-1 i.v.) had no effects on heart rate, on mean arterial or left ventricular pressure, on (dP/dt) Max (2989 +/- 119 vs. 3007 +/- 155 mmHg s-1; NS) or on the relaxation rate. The left ventricular endocardial and epicardial coronary blood flows (radioactive microspheres) and the renal flow in the outer cortex (707-683 ml (min-1 100 g-1); NS) or in the inner cortex (563-570; NS) were also insignificantly affected by AP III infusion. However, AP III increased urinary flow from 24 +/- 6 to 36 +/- 7 ml h-1 (P less than 0.025) and the Na+ and Cl- excretions by 92 and 98%, respectively, (P less than 0.025 and P less than 0.01 vs. saline group) without altering significantly K+, urea and creatinine eliminations. In the moderately hypovolaemic state (mean reduction in renal flow: outer cortex - 15%; P less than 0.05, inner cortex - 5%; NS), AP III infusion at two doses (1 and 3 micrograms kg-1 min-1) still had no effects on arterial pressure and on the indexes of left ventricular inotropic state and relaxation but in this setting, the diuretic effect of AP III became variable. Five dogs markedly increased their excretion of water, Na+ and Cl- whereas no change was noted in the seven remaining dogs.(ABSTRACT TRUNCATED AT 250 WORDS)
B R Habib; C Hanet; H Van Mechelen; A Keyeux; A A Charlier; H Pouleur
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  European journal of clinical investigation     Volume:  16     ISSN:  0014-2972     ISO Abbreviation:  Eur. J. Clin. Invest.     Publication Date:  1986 Dec 
Date Detail:
Created Date:  1987-04-27     Completed Date:  1987-04-27     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0245331     Medline TA:  Eur J Clin Invest     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  461-7     Citation Subset:  IM    
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MeSH Terms
Atrial Natriuretic Factor / pharmacology*
Blood Pressure / drug effects
Diuresis / drug effects
Heart / drug effects*,  physiology
Heart Rate / drug effects
Kidney / drug effects*,  physiology
Myocardial Contraction / drug effects
Regional Blood Flow / drug effects
Shock / physiopathology*
Reg. No./Substance:
85637-73-6/Atrial Natriuretic Factor

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