Document Detail

Effects of atrial natriuretic peptide and cyclic guanosine monophosphate on isolated human myometrial arteries preconstricted by endothelin-1.
MedLine Citation:
PMID:  8529953     Owner:  NLM     Status:  MEDLINE    
In the present in vitro study we investigated the possible vasorelaxing effect of atrial natriuretic peptide (ANP) and cyclic guanosine monophosphate (cGMP) on small intramyometrial arteries precontracted by endothelin-1 (ET-1). Myometrial biopsies from normotensive pregnant women were obtained during cesarean section and arteries of resistance vessel size were dissected and mounted in a tissue chamber for isometric registration of contractile tone. In arteries preconstricted with ET-1 (10(-8)M), ANP produced a concentration-dependent relaxation of 19 +/- 5% (mean +/- SEM) and 27 +/- 7% at concentrations of 10(-7) and 3 x 10(-7) M, respectively. cGMP induced a relaxation of 13 +/- 2, 18 +/- 3, 25 +/- 4 and 30 +/- 7% at concentrations of 10(-5), 10(-4), 3 x 10(-4) and 10(-3) M, respectively. Pretreatment with ANP did not attenuate the contraction produced by ET-1. We suggest that ANP may have a vasodilating effect on preconstricted human uteroplacental vessels. It also provides evidence for the role of other endogenous or exogenous vasodilators acting via cGMP-dependent mechanisms in the counteraction of ET-1-induced contraction of the myometrial resistance vessels during pregnancy.
K R Kublickiene; C Grunewald; M Kublickas; B Lindblom; N O Lunell; H Nisell
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Gynecologic and obstetric investigation     Volume:  40     ISSN:  0378-7346     ISO Abbreviation:  Gynecol. Obstet. Invest.     Publication Date:  1995  
Date Detail:
Created Date:  1996-02-01     Completed Date:  1996-02-01     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7900587     Medline TA:  Gynecol Obstet Invest     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  190-4     Citation Subset:  IM    
Department of Obstetrics and Gynecology, Karolinska Institute, Huddinge University Hospital, Sweden.
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MeSH Terms
Arteries / drug effects*,  physiology
Atrial Natriuretic Factor / pharmacology*
Cesarean Section
Cyclic GMP / pharmacology*
Endothelins / pharmacology*
Myometrium / blood supply*
Vasoconstriction / drug effects
Vasodilation / drug effects
Reg. No./Substance:
0/Endothelins; 7665-99-8/Cyclic GMP; 85637-73-6/Atrial Natriuretic Factor

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