Document Detail

Effects of atrial natriuretic factor on patients with renovascular hypertension.
MedLine Citation:
PMID:  1288975     Owner:  NLM     Status:  MEDLINE    
Previous studies have shown the effects of atrial natriuretic factor (ANF) on rats with renovascular hypertension (RVH). In the present study low dose alpha-hANF (0.025 microgram/kg/min) was administered intravenously for 60 minutes to seven RVH patients. Results demonstrated an inhibition of renin-angiotensin-aldosterone system (RAAS), reduction of plasma catecholamine and arginine vasopressin(AVP), diuresis and natriuresis, increase of hematocrit and creatinine clearance, and slight decrease of blood pressure. These results showed that most factors involved in the establishment and maintenance of RVH are affected by ANF infusion.
W G Zhang; L S Liu; D Y Zheng; G Z Liu; L Jin; X W Zhao; B Ren
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Chinese medical journal     Volume:  105     ISSN:  0366-6999     ISO Abbreviation:  Chin. Med. J.     Publication Date:  1992 Sep 
Date Detail:
Created Date:  1993-03-24     Completed Date:  1993-03-24     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7513795     Medline TA:  Chin Med J (Engl)     Country:  CHINA    
Other Details:
Languages:  eng     Pagination:  732-7     Citation Subset:  IM    
Department of Hypertension, Chinese Academy of Medical Sciences, Beijing.
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MeSH Terms
Arginine Vasopressin / blood
Atrial Natriuretic Factor / therapeutic use*
Blood Pressure / drug effects
Catecholamines / blood
Heart Rate / drug effects
Hypertension, Renovascular / blood,  drug therapy*,  physiopathology
Middle Aged
Renin-Angiotensin System / drug effects
Reg. No./Substance:
0/Catecholamines; 113-79-1/Arginine Vasopressin; 85637-73-6/Atrial Natriuretic Factor

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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