| Effects of atrial natriuretic factor, nitroprusside and acetylcholine on cGMP immunostaining in the isolated perfused rat kidney. | |
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MedLine Citation:
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PMID: 1657837 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In the present study the localization of the cGMP production in response to the vasodilators acetylcholine (ACh) and sodium nitroprusside (SNP) and to atrial natriuretic factor (ANF) was studied in the isolated perfused rat kidney using cGMP immunocytochemistry. After ACh (0.3 microM) infusion increased cGMP immunoreactivity was found in kidney interlobar and segmental arteries and in glomeruli. SNP (1 microM) and ANF (0.01 microM) elevated cGMP staining in the same elements of the kidney as ACh. In the glomeruli ACh and SNP stimulated cGMP production in mesangial cells whereas ANF stimulated cGMP production in mesangial cells whereas ANF stimulated cGMP production in epithelial cells (podocytes). However, SNP at higher doses (10 microM) stimulated cGMP production not only in glomeruli, but also in interstitial cells throughout the cortex. In addition SNP and ANF increased cGMP production in the medulla. |
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Authors:
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H S Berkelmans; G A Burton; J Schipper; J de Vente |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Histochemistry Volume: 96 ISSN: 0301-5564 ISO Abbreviation: Histochemistry Publication Date: 1991 |
Date Detail:
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Created Date: 1991-12-13 Completed Date: 1991-12-13 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0411300 Medline TA: Histochemistry Country: GERMANY |
Other Details:
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Languages: eng Pagination: 13-9 Citation Subset: IM |
Affiliation:
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Department of Pharmacology, Duphar B.V., Weesp, The Netherlands. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acetylcholine
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pharmacology* Animals Atrial Natriuretic Factor / pharmacology* Cyclic GMP / analysis* Immunohistochemistry Kidney / blood supply, chemistry, drug effects* Kidney Cortex / chemistry, drug effects Kidney Medulla / chemistry, drug effects Male Nitroprusside / pharmacology* Rats Rats, Inbred Strains |
| Chemical | |
Reg. No./Substance:
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0/atrial natriuretic peptide, rat; 15078-28-1/Nitroprusside; 51-84-3/Acetylcholine; 7665-99-8/Cyclic GMP; 85637-73-6/Atrial Natriuretic Factor |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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