| Effects of atorvastatin on progression of diabetic nephropathy and local RAGE and soluble RAGE expressions in rats. | |
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MedLine Citation:
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PMID: 21796806 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Objective: Advanced glycation end-products (AGEs) exert inflammatory and oxidative stress insults to produce diabetic nephropathy mainly through the receptor for AGEs (RAGE). This study aimed to assess the effect of atorvastatin on diabetic nephropathy via soluble RAGE (sRAGE) and RAGE expressions in the rat kidney. Methods: Thirty-two male Sprague-Dawley rats were divided into four groups based on the presence or absence of streptozotocin-induced diabetes with or without atorvastatin treatment (10 mg/kg for 24 weeks). Serum sRAGE and glycated albumin (GA) levels were measured with enzyme-linked immunosorbent assay (ELISA) and improved bromocresol purple methods. Renal AGEs, RAGE, endogenous secretory RAGE (esRAGE), and sRAGE were determined with reverse transcription-polymerase chain reaction (RT-PCR) and Western blotting. Results: Mesangial expansion and microalbuminuria were aggravated in diabetic rats, and improved with atorvastatin treatment. Serum sRAGE levels were lower in diabetic than in normal rats. After atorvastatin treatment, serum and renal sRAGE levels were up-regulated, while renal RAGE expression was decreased in diabetic rats, associated with a reduction in accumulation of AGEs, though renal esRAGE mRNA expression was not significantly increased. Conclusions: Atorvastatin exerted a beneficial effect on diabetic nephropathy with reduced AGE accumulation, down-regulating RAGE expression and up-regulating sRAGE in the kidney. |
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Authors:
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Lin Lu; Wen-Hui Peng; Wei Wang; Ling-Jie Wang; Qiu-Jing Chen; Wei-Feng Shen |
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Publication Detail:
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Type: JOURNAL ARTICLE |
Journal Detail:
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Title: Journal of Zhejiang University. Science. B Volume: 12 ISSN: 1862-1783 ISO Abbreviation: - Publication Date: 2011 Aug. |
Date Detail:
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Created Date: 2011-7-28 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101236535 Medline TA: J Zhejiang Univ Sci B Country: - |
Other Details:
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Languages: ENG Pagination: 652-659 Citation Subset: - |
Affiliation:
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Department of Cardiology, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200025, China; Institute of Cardiovascular Diseases, School of Medicine, Shanghai Jiao Tong University, Shanghai 200025, China. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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