Document Detail

Effects of atherosclerosis on mean and daily variation of arterial pressure in conscious WHHL rabbits.
MedLine Citation:
PMID:  1391177     Owner:  NLM     Status:  MEDLINE    
Effects of atherosclerosis on the mean value and daily variation of arterial pressure were studied in 12 Watanabe-heritable hyperlipidemic (WHHL) rabbits aged 12 to 35 months and 25 normal Japanese white rabbits aged 6 to 30 months. A pressure catheter was inserted through the left subclavian artery under pentobarbital anesthesia. A few days after the catheterization, the mean arterial pressure (MAP) of the rabbits, which were active and in a good state of appetite, was recorded by an analogue-to-digital converter every second for about 6 hrs and stored in a computer. The mean (M) and standard deviation (SD) in the WHHL rabbit, calculated from each successive MAP record, ranged widely from 85.8 to 131.4 mmHg and 5.6 to 12.6 mmHg, respectively. There was no significant correlation between M and SD in the WHHL rabbit. M and variance (V) of MAP in the WHHL rabbit were significantly higher than those in the normal rabbit. M did not show any significant change with increasing ages, whereas SD increased significantly with aging in the WHHL rabbit. Concentrations of serum total cholesterol and triglyceride in the WHHL rabbit were 475 and 328 mg/dl, which were about nine and seven times as high as those in the normal rabbit, respectively. Macroscopic and histopathological examinations of the aorta revealed development and spread of sclerotic lesions with aging in the WHHL rabbit. We can conclude that development of atherosclerosis with aging in the WHHL rabbit causes malfunction of the baroreceptors, which contributes to hypertension and lability of arterial pressure.
S Katsuda; H Hosomi; M Shiomi; Y Watanabe
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of veterinary medical science / the Japanese Society of Veterinary Science     Volume:  54     ISSN:  0916-7250     ISO Abbreviation:  J. Vet. Med. Sci.     Publication Date:  1992 Aug 
Date Detail:
Created Date:  1992-11-06     Completed Date:  1992-11-06     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  9105360     Medline TA:  J Vet Med Sci     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  669-73     Citation Subset:  IM    
Department of Nutritional Physiology, Nippon Meat Packers, Inc., Ibaraki, Japan.
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MeSH Terms
Aging / physiology
Aorta / pathology
Aorta, Thoracic / pathology
Arteriosclerosis / pathology,  physiopathology*
Blood Pressure*
Carotid Arteries / pathology
Cholesterol / blood
Coronary Vessels / pathology
Disease Models, Animal*
Triglycerides / blood
Reg. No./Substance:
0/Triglycerides; 57-88-5/Cholesterol

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