Document Detail

Effects of atherogenic diet on young farm pigs.
MedLine Citation:
PMID:  1740169     Owner:  NLM     Status:  MEDLINE    
This study was designed to assess the usefulness of young farm pigs as an experimental model for hypercholesterolemia. In order to test this, we investigated both serologic and electrocardiographic effects of atherogenic diet. Four-week-old pigs were fed an atherogenic diet for 8 weeks. No arrhythmia was observed on ECG in all animals. There were no significant difference between control and atherogenic diet group on the values of ECG parameters. However, plasma lipids values of atherogenic diet group were significantly (p less than 0.05) higher than those of control diet group. Thus, hypercholesterolemia was induced in young farm pigs by feeding atherogenic diet in a relatively short time. This fact suggests that young farm pigs may be an useful model for further studies of the effect of hypercholesterolemia on cardiovascular function and the early pathogenesis of atherosclerosis.
M Kuwahara; S Sugano
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Jikken dobutsu. Experimental animals     Volume:  41     ISSN:  0007-5124     ISO Abbreviation:  Jikken Dobutsu     Publication Date:  1992 Jan 
Date Detail:
Created Date:  1992-03-23     Completed Date:  1992-03-23     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  1256412     Medline TA:  Jikken Dobutsu     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  71-3     Citation Subset:  IM    
Department of Comparative Pathophysiology, Faculty of Agriculture, University of Tokyo, Japan.
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MeSH Terms
Diet, Atherogenic*
Disease Models, Animal*
Hypercholesterolemia* / blood,  etiology,  physiopathology
Lipids / blood
Reg. No./Substance:

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