| Effects of astilbic acid on airway hyperresponsiveness and inflammation in a mouse model of allergic asthma. | |
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MedLine Citation:
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PMID: 21168540 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Bronchial asthma is characterized by chronic lung inflammation, airway hyperresponsiveness (AHR), and airway remodeling. Astilbic acid, extracted from the medicinal herb Astilbe chinensis, is used as a headache remedy in traditional medicine and has anti-pyretic and analgesic effects. However, the effect of astilbic acid on asthma remains to be established. In the present study, we therefore examined the effect of astilbic acid in a mouse model in which asthma was established by sensitization and challenge with ovalbumin (OVA). Astilbic acid inhibited OVA-induced AHR to inhaled methacholine and significantly suppressed the levels of T-helper 2-type cytokines (including IL [interleukin]-4, IL-5, and IL-13) and inflammatory cells (including eosinophils) in bronchoalveolar lavage (BAL) fluid. Histochemical analysis revealed reduced goblet cell hyperplasia and mucus production, as well as attenuated eosinophil-rich leukocyte infiltration, in the astilbic acid-treated group, compared with OVA-challenged mice. Moreover, the compound significantly inhibited synthesis of IL-4-, IL-5-, IL-13-, IL-17-, and eotaxin-encoding mRNA following asthma induction in lung tissue, in addition to suppressing the immunoglobulin E (IgE) response to asthma in both BAL fluid and serum. Our results indicate that astilbic acid has great potential as a therapeutic candidate for the treatment of asthma. |
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Authors:
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Ji-Eun Yuk; Mee-Young Lee; Ok-Kyoung Kwon; Xing-Fu Cai; Ha-Young Jang; Sei-Ryang Oh; Hyeong-Kyu Lee; Kyung-Seop Ahn |
Publication Detail:
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Type: Journal Article Date: 2010-12-17 |
Journal Detail:
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Title: International immunopharmacology Volume: 11 ISSN: 1878-1705 ISO Abbreviation: Int. Immunopharmacol. Publication Date: 2011 Feb |
Date Detail:
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Created Date: 2011-01-25 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100965259 Medline TA: Int Immunopharmacol Country: Netherlands |
Other Details:
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Languages: eng Pagination: 266-73 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 Elsevier B.V. All rights reserved. |
Affiliation:
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Immune Modulator Research Center, Korea Research Institute of Bioscience and Biotechnology, Yang-chung ri, O-chang uep, 363-883, Republic of Korea. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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