| Effects of aspirin on nasal responses in atopic subjects. | |
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MedLine Citation:
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PMID: 6350409 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Preliminary experiments indicated that solutions of aspirin (ASA) in buffered saline, pH 7.35, did not significantly change nasal airways resistance (NAR) when 0.1 ml of solution containing 22.5 mg (or less) per deciliter was sprayed into each nostril. Subsequently it was shown that this quantity of ASA administered intranasally did not significantly change NAR responses 15 min later to intranasal administration of increasing concentrations of histamine, methacholine, or an irritant (NH3 gas). However, the same atopic subjects demonstrated significantly decreased responses to intranasal challenge with short ragweed extract (SRW) after intranasal ASA. In addition, prior oral administration of ASA, Na salicylate, and indomethacin significantly inhibited nasal challenge responses to SRW in sensitive subjects under controlled conditions. |
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Authors:
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J A McLean; J R Bacon; K P Mathews; J Banas; D Capati; N K Bayne |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: The Journal of allergy and clinical immunology Volume: 72 ISSN: 0091-6749 ISO Abbreviation: J. Allergy Clin. Immunol. Publication Date: 1983 Aug |
Date Detail:
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Created Date: 1983-10-08 Completed Date: 1983-10-08 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 1275002 Medline TA: J Allergy Clin Immunol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 187-92 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Intranasal Administration, Oral Airway Resistance / drug effects* Allergens / administration & dosage Aspirin / administration & dosage* Binding, Competitive Histamine / administration & dosage Humans Methacholine Chloride Methacholine Compounds / administration & dosage Nasal Provocation Tests* Rhinitis, Allergic, Seasonal / diagnosis, drug therapy, immunology* Solutions |
| Grant Support | |
ID/Acronym/Agency:
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AI 10391/AI/NIAID NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Allergens; 0/Methacholine Compounds; 0/Solutions; 50-78-2/Aspirin; 51-45-6/Histamine; 62-51-1/Methacholine Chloride |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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