Document Detail

Effects of aspirin on nasal responses in atopic subjects.
MedLine Citation:
PMID:  6350409     Owner:  NLM     Status:  MEDLINE    
Preliminary experiments indicated that solutions of aspirin (ASA) in buffered saline, pH 7.35, did not significantly change nasal airways resistance (NAR) when 0.1 ml of solution containing 22.5 mg (or less) per deciliter was sprayed into each nostril. Subsequently it was shown that this quantity of ASA administered intranasally did not significantly change NAR responses 15 min later to intranasal administration of increasing concentrations of histamine, methacholine, or an irritant (NH3 gas). However, the same atopic subjects demonstrated significantly decreased responses to intranasal challenge with short ragweed extract (SRW) after intranasal ASA. In addition, prior oral administration of ASA, Na salicylate, and indomethacin significantly inhibited nasal challenge responses to SRW in sensitive subjects under controlled conditions.
J A McLean; J R Bacon; K P Mathews; J Banas; D Capati; N K Bayne
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The Journal of allergy and clinical immunology     Volume:  72     ISSN:  0091-6749     ISO Abbreviation:  J. Allergy Clin. Immunol.     Publication Date:  1983 Aug 
Date Detail:
Created Date:  1983-10-08     Completed Date:  1983-10-08     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  1275002     Medline TA:  J Allergy Clin Immunol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  187-92     Citation Subset:  AIM; IM    
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MeSH Terms
Administration, Intranasal
Administration, Oral
Airway Resistance / drug effects*
Allergens / administration & dosage
Aspirin / administration & dosage*
Binding, Competitive
Histamine / administration & dosage
Methacholine Chloride
Methacholine Compounds / administration & dosage
Nasal Provocation Tests*
Rhinitis, Allergic, Seasonal / diagnosis,  drug therapy,  immunology*
Grant Support
Reg. No./Substance:
0/Allergens; 0/Methacholine Compounds; 0/Solutions; 50-78-2/Aspirin; 51-45-6/Histamine; 62-51-1/Methacholine Chloride

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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