Document Detail

Effects of ascorbic acid on cadmium-induced oxidative stress and performance of broilers.
MedLine Citation:
PMID:  15851829     Owner:  NLM     Status:  MEDLINE    
The effects of cadmium on performance, antioxidant defense system, liver and kidney functions, and cadmium accumulation in selected tissues of broiler chickens were studied. Whether the possible adverse effects of cadmium would reverse with the antioxidant ascorbic acid was also investigated. Hence, 4 treatment groups (3 replicates of 10 chicks each) were designed in the study: control, ascorbic acid, cadmium, and cadmium plus ascorbic acid. Cadmium was given via the drinking water at a concentration of 25 mg/L for 6 wk. Ascorbic acid was added to the basal diet at 200 mg/kg either alone or with cadmium. Cadmium decreased the body weight (BW), body weight gain (BWG), and feed efficiency (FE) significantly at the end of the experiment, whereas its effect on feed consumption (FC) was not significant. Cadmium increased the plasma malondialdehyde (MDA) level as an indicator of lipid peroxidation and lowered the activity of blood superoxide dismutase (SOD). Liver function enzymes, aspartate aminotransferase (AST), alanine aminotransferase (ALT), lactate dehydrogenase (LDH), and gamma glutamyl transferase (GGT) activities were not changed by cadmium. Cadmium ingestion did not alter serum creatinine levels. Although the serum cadmium level was not elevated, cadmium mainly accumulated in the kidneys, liver, pancreas, and muscle. Ascorbic acid supplementation resulted in a reduction of MDA level previously increased by cadmium and a restoration in SOD activity. However, ascorbic acid did not ameliorate the growth inhibitory effect of cadmium nor did it prevent accumulation of cadmium in analyzed tissues. These data indicate that oxidative stress, induced by cadmium, plays a role in decreasing the performance of broilers and that dietary supplementation by ascorbic acid might be useful in reversing the lipid peroxidation induced by cadmium and partly alleviating the adverse effect of cadmium on performance of broilers.
Zeynep Erdogan; Suat Erdogan; Sefa Celik; Ali Unlu
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Biological trace element research     Volume:  104     ISSN:  0163-4984     ISO Abbreviation:  Biol Trace Elem Res     Publication Date:  2005 Apr 
Date Detail:
Created Date:  2005-04-26     Completed Date:  2005-06-27     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7911509     Medline TA:  Biol Trace Elem Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  19-32     Citation Subset:  IM    
Department of Animal Nutrition and Nutritional Diseases, Mustafa Kemal University, Faculty of Veterinary Medicine, Antakya-Hatay, Turkey.
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MeSH Terms
Antioxidants / pharmacology*
Ascorbic Acid / pharmacology*
Body Weight / drug effects
Cadmium / blood,  pharmacokinetics
Cadmium Poisoning / metabolism*
Chickens / growth & development*,  physiology*
Eating / drug effects
Lipid Peroxidation / drug effects
Malondialdehyde / blood
Oxidative Stress / drug effects*
Superoxide Dismutase / blood
Tissue Distribution
Weight Gain / drug effects
Reg. No./Substance:
0/Antioxidants; 50-81-7/Ascorbic Acid; 542-78-9/Malondialdehyde; 7440-43-9/Cadmium; EC Dismutase

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