| Effects of asbestos fibers on alveolar macrophage-mediated lymphocyte cytostasis. | |
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MedLine Citation:
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PMID: 3709494 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Prolonged asbestos inhalation results in pulmonary inflammation and fibrosis. Since alveolar macrophages are active in regulation of immune responses in lung and appear to be involved in the pathogenesis of asbestosis, we evaluated the effects of asbestos exposure on the ability of these cells to regulate lymphocyte function. Alveolar macrophages obtained by lung lavage from BALB/C mice were treated in vitro with either UICC amosite or chrysotile asbestos and the effects on lymphocyte cytostasis compared with those of macrophages incubated with latex beads or zymosan. Macrophages (10%) incubated either alone or with latex beads for 48 hr effectively inhibited lymphocyte mitogenesis. However, alveolar macrophages incubated with either amosite or chrysotile asbestos did not demonstrate intact cytostatic activity. Decreased viability of chrysotile asbestos-treated macrophages correlated with loss of cytostatic effects, but alveolar macrophages exposed to amosite remained viable. We conclude, therefore, that exposure of alveolar macrophages to asbestos can result in loss of their ability to down-regulate lymphocyte proliferation, a finding which may be important in the pathogenesis of asbestos-related disease. |
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Authors:
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B E Bozelka; P Sestini; Y Hammad; J E Salvaggio |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Environmental research Volume: 40 ISSN: 0013-9351 ISO Abbreviation: Environ. Res. Publication Date: 1986 Jun |
Date Detail:
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Created Date: 1986-06-30 Completed Date: 1986-06-30 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0147621 Medline TA: Environ Res Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 172-80 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Asbestos / immunology*, pharmacology Asbestosis / etiology, immunology* Cell Survival Cells, Cultured Female Lymphocyte Activation / drug effects Mice Mice, Inbred BALB C Pulmonary Alveoli / immunology* Spleen / immunology |
| Grant Support | |
ID/Acronym/Agency:
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HL-15092-13/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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1332-21-4/Asbestos |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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