| Effects of arterial blood pressure on rebleeding using Celox and TraumaDEX in a porcine model of lethal femoral injury. | |
| | |
MedLine Citation:
|
PMID: 20572410 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
This study was designed to identify the systolic blood pressure (SBP) and mean arterial pressure (MAP) at which rebleeding occurs when a clot is formed by a hemostatic agent, Celox or TraumaDEX, compared with a standard dressing. Fifteen pigs (5 each) were assigned randomly to 1 of 3 groups: Celox, TraumaDEX, or standard pressure dressing as a control. In all animals, the femoral artery and vein were transected to simulate traumatic injury. Subjects were allowed to hemorrhage 1 minute before treatment. Direct pressure was held 5 minutes followed by application of elastic dressings for 30 minutes. Dressings were removed after 30 minutes, and the wound was observed for rebleeding. Animals demonstrating hemostasis received phenylephrine infusion to increase SBP in 10-mm Hg increments until SBP reached 210 mm Hg or hemorrhage recurred. There were statistically significant differences between Celox (mean SBP, 166.4 mm Hg; mean MAP, 1376 mm Hg) and the control (mean SBP, 88.25 mm Hg; mean MAP, 59.7 mm Hg), and between TraumaDEX (mean SBP, 152.2 mm Hg; mean MAP, 113.2 mm Hg) and the control (P < .05). However, no statistically significant difference existed between Celox and TraumaDEX. Celox and TraumaDEX effectively prevent rebleeding compared with standard dressing. |
| | |
Authors:
|
James M Burgert; Brian T Gegel; Robert Austin; Alejandro Davila; Jacob Deeds; Lonnie Hodges; Andrew Hover; Cheryl Lockhart; John Roy; Glenn Simpson; Stephen Weaver; William Wolfe; Don Johnson |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: AANA journal Volume: 78 ISSN: 0094-6354 ISO Abbreviation: AANA J Publication Date: 2010 Jun |
Date Detail:
|
Created Date: 2010-06-24 Completed Date: 2010-07-27 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0431420 Medline TA: AANA J Country: United States |
Other Details:
|
Languages: eng Pagination: 230-6 Citation Subset: N |
Affiliation:
|
U.S. Army Graduate Program in Anesthesia Nursing, Brooke Army Medical Center, Fort Sam Houston, Texas, USA. james.burgert1@us.army.mil |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Analysis of Variance Animals Biopolymers / therapeutic use* Blood Pressure* / drug effects Disease Models, Animal Femoral Artery / injuries* Hemorrhage / drug therapy*, etiology Hemostatics / therapeutic use* Hypertension / chemically induced, complications Male Microspheres Phenylephrine / adverse effects Polysaccharides / therapeutic use* Prospective Studies Random Allocation Recurrence Swine Systole Vasoconstrictor Agents / adverse effects |
| Chemical | |
Reg. No./Substance:
|
0/Biopolymers; 0/Celox; 0/Hemostatics; 0/Polysaccharides; 0/TraumaDEX; 0/Vasoconstrictor Agents; 59-42-7/Phenylephrine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Case report: anesthetic management of acute fatty liver of pregnancy in the postpartum period.
Next Document: Apoptosis: understanding programmed cell death for the CRNA.