Document Detail

Effects of arsenic trioxide inhalation exposure on pulmonary antibacterial defenses in mice.
MedLine Citation:
PMID:  3884825     Owner:  NLM     Status:  MEDLINE    
The effects of single and multiple (5 and 20) 3-h inhalation exposures to aerosols of arsenic trioxide on the pulmonary defense system of mice were investigated. Arsenic trioxide mist was generated from an aqueous solution and dried to produce particulate aerosols of 0.4 micron mass median aerodynamic diameter. Aerosol mass concentration ranged from 125 to 1000 micrograms As/m3. Effects of the exposures were evaluated by determination of changes in susceptibility to experimentally induced streptococcal aerosol infection and in pulmonary bactericidal activity to 35S-labeled Klebsiella pneumoniae. Significant increases in mortality due to the infectious challenge and decreases in bactericidal activity were seen after single 3-h exposures to 270, 500, and 940 micrograms As/m3. Similarly, 5 or 20 multiple 3-h exposures to 500 micrograms As/m3 produced consistently significant increases in mortality and decreases in pulmonary bactericidal activity. At 125 or 250 micrograms As/m3, a decrease in bactericidal activity was seen only after 20 exposures to 250 micrograms/m3. Results from earlier studies with an arsenic-containing copper smelter dust were compared to these data. The possibility of the development of adaptation during multiple exposures to arsenic trioxide is also considered.
C Aranyi; J N Bradof; W J O'Shea; J A Graham; F J Miller
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Journal of toxicology and environmental health     Volume:  15     ISSN:  0098-4108     ISO Abbreviation:  J Toxicol Environ Health     Publication Date:  1985  
Date Detail:
Created Date:  1985-05-08     Completed Date:  1985-05-08     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7513622     Medline TA:  J Toxicol Environ Health     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  163-72     Citation Subset:  IM; S    
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MeSH Terms
Arsenic / toxicity*
Atmosphere Exposure Chambers
Klebsiella pneumoniae / drug effects*
Lung / drug effects*
Pneumococcal Infections / chemically induced*,  mortality
Sulfur Radioisotopes
Reg. No./Substance:
0/Aerosols; 0/Arsenicals; 0/Oxides; 0/Sulfur Radioisotopes; 1327-53-3/arsenic trioxide; 7440-38-2/Arsenic

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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