Document Detail


Effects of arotinoids upon murine embryonal carcinoma cells.
MedLine Citation:
PMID:  6307509     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Five arotinoids have been compared with all-trans- and 13-cisretinoic acids for their ability to promote differentiation of cells from murine embryonal carcinoma line Nulli-SCC1. Ro-13-7410, which contains a terminal carboxylic acid residue, and Ro-14-9572, the sodium sulfinate derivative, are potent inducers of differentiation. The sodium sulfonate derivative, Ro-14-3899, is somewhat less active, whereas the ethyl sulfone (Ro-15-1570) and Ro-15-0778, an arotinoid lacking a terminal group, have little or no effect on embryonal carcinoma cell differentiation. Competition by the arotinoids with all-trans-retinoic acid for sites on the cellular retinoic acid-binding protein is qualitatively consistent with their capacity for promoting differentiation. This relationship and the response of differentiation-defective embryonal carcinoma cells to Ro-13-7410 support the view that arotinoids and retinoids promote differentiation of embryonal carcinoma cells via the same mechanism.
Authors:
M I Sherman; M L Paternoster; M Taketo
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Cancer research     Volume:  43     ISSN:  0008-5472     ISO Abbreviation:  Cancer Res.     Publication Date:  1983 Sep 
Date Detail:
Created Date:  1983-09-23     Completed Date:  1983-09-23     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  2984705R     Medline TA:  Cancer Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  4283-90     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Benzoates / pharmacology*
Carrier Proteins / metabolism
Cell Division / drug effects
Cell Line
Isomerism
Kinetics
Mice
Neoplasm Proteins / metabolism
Neoplasms, Experimental / physiopathology
Receptors, Retinoic Acid
Retinoids*
Structure-Activity Relationship
Teratoma / physiopathology*
Tretinoin / metabolism
Vitamin A / pharmacology*
Chemical
Reg. No./Substance:
0/Benzoates; 0/Carrier Proteins; 0/Neoplasm Proteins; 0/Receptors, Retinoic Acid; 0/Retinoids; 11103-57-4/Vitamin A; 302-79-4/Tretinoin; 71441-28-6/4-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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