| Effects of arotinoids upon murine embryonal carcinoma cells. | |
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MedLine Citation:
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PMID: 6307509 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Five arotinoids have been compared with all-trans- and 13-cisretinoic acids for their ability to promote differentiation of cells from murine embryonal carcinoma line Nulli-SCC1. Ro-13-7410, which contains a terminal carboxylic acid residue, and Ro-14-9572, the sodium sulfinate derivative, are potent inducers of differentiation. The sodium sulfonate derivative, Ro-14-3899, is somewhat less active, whereas the ethyl sulfone (Ro-15-1570) and Ro-15-0778, an arotinoid lacking a terminal group, have little or no effect on embryonal carcinoma cell differentiation. Competition by the arotinoids with all-trans-retinoic acid for sites on the cellular retinoic acid-binding protein is qualitatively consistent with their capacity for promoting differentiation. This relationship and the response of differentiation-defective embryonal carcinoma cells to Ro-13-7410 support the view that arotinoids and retinoids promote differentiation of embryonal carcinoma cells via the same mechanism. |
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Authors:
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M I Sherman; M L Paternoster; M Taketo |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Cancer research Volume: 43 ISSN: 0008-5472 ISO Abbreviation: Cancer Res. Publication Date: 1983 Sep |
Date Detail:
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Created Date: 1983-09-23 Completed Date: 1983-09-23 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 2984705R Medline TA: Cancer Res Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 4283-90 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Benzoates / pharmacology* Carrier Proteins / metabolism Cell Division / drug effects Cell Line Isomerism Kinetics Mice Neoplasm Proteins / metabolism Neoplasms, Experimental / physiopathology Receptors, Retinoic Acid Retinoids* Structure-Activity Relationship Teratoma / physiopathology* Tretinoin / metabolism Vitamin A / pharmacology* |
| Chemical | |
Reg. No./Substance:
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0/Benzoates; 0/Carrier Proteins; 0/Neoplasm Proteins; 0/Receptors, Retinoic Acid; 0/Retinoids; 11103-57-4/Vitamin A; 302-79-4/Tretinoin; 71441-28-6/4-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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