Document Detail

Effects of arachidonic acid and its cyclo-oxygenase and lipoxygenase products on lymphatic vessel contractility in vitro.
MedLine Citation:
PMID:  6133315     Owner:  NLM     Status:  MEDLINE    
Lymphatic vessels exhibit rhythmical contractility in vivo and in vitro and this activity appears to regulate lymph flow. A technique for measuring the circular muscle contractions of isolated bovine mesenteric lymphatic vessel segments has been devised and utilized to study the pharmacological properties of these vessels. Non-contracting lymphatic vessels can be induced to contract rhythmically with a variety of mediators, the most potent being a stable PGH2 analogue (compound U46619), and the leukotrienes B4, C4 and D4 (threshold concentrations in the nanomolar range). Prostaglandin F2 alpha, noradrenaline, serotonin and histamine also elicited rhythmical activity but much higher concentrations were required. PGE2 and PGE1 were potent inhibitors of spontaneous contractions or those induced with U46619. In keeping with the diverse pharmacological effects of the metabolites of arachidonic acid, the addition of arachidonate to an isolated lymphatic vessel generated both stimulatory and inhibitory activities. It is concluded that arachidonic acid products (produced in the lymphatic vessel or entering the vessel in lymph draining the tissues) regulate lymph flow through their effects on lymphatic smooth muscle.
M G Johnston; A Kanalec; J L Gordon
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Prostaglandins     Volume:  25     ISSN:  0090-6980     ISO Abbreviation:  Prostaglandins     Publication Date:  1983 Jan 
Date Detail:
Created Date:  1983-06-10     Completed Date:  1983-06-10     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0320271     Medline TA:  Prostaglandins     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  85-98     Citation Subset:  IM    
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MeSH Terms
Arachidonic Acid
Arachidonic Acids / pharmacology*
Leukotriene B4 / pharmacology
Lipoxygenase / metabolism*
Lymphatic System / drug effects*,  metabolism
Muscle Contraction / drug effects
Muscle, Smooth / drug effects*
Neurotransmitter Agents / pharmacology
Prostaglandin-Endoperoxide Synthases / metabolism*
Prostaglandins E / pharmacology
SRS-A / pharmacology
Reg. No./Substance:
0/Arachidonic Acids; 0/Neurotransmitter Agents; 0/Prostaglandins E; 0/SRS-A; 363-24-6/Dinoprostone; 506-32-1/Arachidonic Acid; 71160-24-2/Leukotriene B4; 745-65-3/Alprostadil; EC; EC Synthases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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