| Effects of apomorphine and diazepam on a quickly learned conditioned suppression in rats. | |
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MedLine Citation:
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PMID: 7122668 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Electric shock experienced rats exhibited a marked suppression of motor activity when placed in the same environment in which the animal received shocks. At 24 hr after electrical shocks, the shock frequencies of 1/10 Hz to 1/180 Hz equally produced a marked suppression of motility. However, electric shock experienced rats exhibited a similar degree of locomotor activity that was seen with the non-shocked rats, when the motility of the animals was measured by using Animex system at 24 hr after electrical shocks. Therefore, this suppression of motility was found to be a consistent response and to be a conditioned response to the environment. Diazepam (1.2.5 or 5 mg/kg, IP) did not show any effect on the conditioned suppression. Apomorphine-HCl (0.1, 0.5 or 1 mg/kg, IP) caused attenuation of the conditioned suppression in relation to dose, but did not increase motor activity of the non-shocked rats. Thus, conditioned suppression caused by a quick conditioning technique may not be associated with anxiety. |
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Authors:
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T Kameyama; M Nagasaka |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Pharmacology, biochemistry, and behavior Volume: 17 ISSN: 0091-3057 ISO Abbreviation: Pharmacol. Biochem. Behav. Publication Date: 1982 Jul |
Date Detail:
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Created Date: 1982-12-02 Completed Date: 1982-12-02 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0367050 Medline TA: Pharmacol Biochem Behav Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 59-63 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Apomorphine / pharmacology* Conditioning, Operant / drug effects* Diazepam / pharmacology* Environment Male Motor Activity / drug effects Rats Rats, Inbred Strains Time Factors |
| Chemical | |
Reg. No./Substance:
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439-14-5/Diazepam; 58-00-4/Apomorphine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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