Document Detail


Effects of the apolipoprotein(a) size polymorphism on the lipoprotein(a) concentration in 7 ethnic groups.
MedLine Citation:
PMID:  2026424     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Apolipoprotein(a) [apo(a)] exhibits a genetic size polymorphism explaining about 40% of the variability in lipoprotein(a) [Lp(a)] concentration in Tyroleans. Lp(a) concentrations and apo(a) phenotypes were determined in 7 ethnic groups (Tyrolean, Icelandic, Hungarian, Malay, Chinese, Indian, Black Sudanese) and the effects of the apo(a) size polymorphism on Lp(a) levels were estimated in each group. Average Lp(a) concentrations were highly significantly different among these populations, with the Chinese (7.0 mg/dl) having the lowest and the Sudanese (46 mg/dl) the highest levels. Apo(a) phenotype and derived apo(a) allele frequencies were also significantly different among the populations. Apo(a) isoform effects on Lp(a) levels were not significantly different among populations. Lp(a) levels were however roughly twice as high in the same phenotypes in the Indians, and several times as high in the Sudanese, compared with Caucasians. The size variation of apo(a) explains from 0.77 (Malays) to only 0.19 (Sudanese) of the total variability in Lp(a) levels. Together these data show (I) that there is considerable heterogeneity of the Lp(a) polymorphism among populations, (II) that differences in apo(a) allele frequencies alone do not explain the differences in Lp(a) levels among populations and (III) that in some populations, e.g. Sudanese Blacks, Lp(a) levels are mainly determined by factors that are different from the apo(a) size polymorphism.
Authors:
C Sandholzer; D M Hallman; N Saha; G Sigurdsson; C Lackner; A Császár; E Boerwinkle; G Utermann
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Human genetics     Volume:  86     ISSN:  0340-6717     ISO Abbreviation:  Hum. Genet.     Publication Date:  1991 Apr 
Date Detail:
Created Date:  1991-06-10     Completed Date:  1991-06-10     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7613873     Medline TA:  Hum Genet     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  607-14     Citation Subset:  IM    
Affiliation:
Institut für Medizinische Biologie und Humangenetik der Universität, Innsbruck, Austria.
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MeSH Terms
Descriptor/Qualifier:
Adult
Alleles
Apolipoproteins / genetics*,  metabolism
Austria
China
Continental Population Groups / genetics*
Electrophoresis, Polyacrylamide Gel
Female
Gene Frequency
Humans
Hungary
Iceland
India
Lipoproteins / blood*
Malaysia
Male
Middle Aged
Phenotype
Polymorphism, Genetic*
Sudan
Chemical
Reg. No./Substance:
0/Apolipoproteins; 0/Lipoproteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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