Document Detail

Effects of antituberculosis treatment on self assessment, perceptual analysis and acoustic analysis of voice quality in laryngeal tuberculosis patients.
MedLine Citation:
PMID:  17592656     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: To evaluate the effects of antituberculosis treatment on the voice quality of laryngeal tuberculosis patients, measured by patient self-assessment, perceptual analysis and acoustic analysis. MATERIALS AND METHODS: A total of 14 laryngeal tuberculosis patients were enrolled. Laryngeal tuberculosis was established either by biopsy and histopathological examination or by rapid regression of the laryngeal lesions after antituberculosis medication. Before and after treatment, all patients were evaluated perceptually (on a scale of zero to three), and 12 assessed their own voices using the voice handicap index-10 scale. Acoustic analysis was performed to allow objective evaluation. RESULTS: Patients' ages ranged from 21 to 72 years (mean, 41). The male to female ratio was 12:2. Eight patients (57 per cent) had tuberculous involvement of the epiglottis, four (28 per cent) had involvement of the aryepiglottic fold and eight (57 per cent) had involvement of the false vocal folds. The glottis was the less commonly involved part of the larynx, including true vocal folds (28 per cent, n = 4) and posterior commissure (14 per cent, n = 2). Perceptual evaluation, on a scale of zero to three, gave the patients a median score of six; after commencement of treatment, the median score decreased to two. The mean voice handicap index-10 score decreased from 24 to 12 after treatment. An obvious improvement in acoustic analytical parameters was also found following treatment. CONCLUSIONS: Antituberculosis treatment clearly improved the voice outcomes of laryngeal tuberculosis patients, according to self-assessment, perceptual analysis and acoustic analysis.
K Yelken; M Guven; M Topak; E Gultekin; F Turan
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Publication Detail:
Type:  Clinical Trial; Journal Article     Date:  2007-06-25
Journal Detail:
Title:  The Journal of laryngology and otology     Volume:  122     ISSN:  1748-5460     ISO Abbreviation:  J Laryngol Otol     Publication Date:  2008 Apr 
Date Detail:
Created Date:  2008-04-04     Completed Date:  2008-06-16     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8706896     Medline TA:  J Laryngol Otol     Country:  England    
Other Details:
Languages:  eng     Pagination:  378-82     Citation Subset:  AIM; IM    
Department of Otolaryngology, Medical Faculty, Gaziomanpasa University, Tokat, Turkey.
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MeSH Terms
Antitubercular Agents / therapeutic use*
Middle Aged
Prospective Studies
Self Assessment (Psychology)
Severity of Illness Index
Sound Spectrography / methods
Speech Perception
Treatment Outcome
Tuberculosis, Laryngeal / complications,  diagnosis,  drug therapy*,  pathology
Voice Disorders / diagnosis,  microbiology*
Voice Quality / drug effects*
Reg. No./Substance:
0/Antitubercular Agents

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