Document Detail

Effects of antiserum against alpha-rat atrial natriuretic polypeptide in spontaneously hypertensive rats.
MedLine Citation:
PMID:  2529780     Owner:  NLM     Status:  MEDLINE    
To clarify the physiological role of endogenous atrial natriuretic polypeptide (ANP), we investigated the effects of specific rabbit antiserum against alpha-rat ANP (alpha-rANP) on hemodynamics, diuresis, and natriuresis in spontaneously hypertensive rats (SHR) and Wistar-Kyoto rats (WKY). Intravenous administration of anti-alpha-rANP antiserum caused an obvious rise of mean blood pressure and cardiac output in both SHR and WKY compared with rats administered with normal rabbit serum. Although there was no significant difference in increments of mean blood pressure between SHR and WKY, the increment of cardiac output in SHR was significantly higher than that in WKY. On the other hand, significant reductions in urine output and urinary sodium and potassium excretion lasted for approximately 20 min after administration of the antiserum in both SHR and WKY compared with rats administered with normal rabbit serum. There was no significant difference in these initial maximal decrements between SHR and WKY. These results indicate that endogenous ANP has an important physiological role in the regulation of hemodynamics and water-electrolyte balance in both SHR and WKY. The greater increment of cardiac output in SHR in response to the antiserum suggests that endogenous ANP in SHR may have a stronger cardiosuppressive action that it does in WKY.
A Sasaki; O Kida; T Kita; J Kato; S Nakamura; K Kodama; A Miyata; K Kangawa; H Matsuo; K Tanaka
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The American journal of physiology     Volume:  257     ISSN:  0002-9513     ISO Abbreviation:  Am. J. Physiol.     Publication Date:  1989 Oct 
Date Detail:
Created Date:  1989-11-17     Completed Date:  1989-11-17     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0370511     Medline TA:  Am J Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  H1104-9     Citation Subset:  IM    
First Department of Internal Medicine, Miyazaki Medical College, Japan.
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MeSH Terms
Atrial Natriuretic Factor / immunology,  physiology*
Blood Pressure
Heart Rate
Immune Sera*
Potassium / urine
Rats, Inbred SHR / physiology*
Rats, Inbred Strains / physiology*
Rats, Inbred WKY / physiology
Sodium / urine
Stroke Volume
Vascular Resistance
Reg. No./Substance:
0/Immune Sera; 7440-09-7/Potassium; 7440-23-5/Sodium; 85637-73-6/Atrial Natriuretic Factor

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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