Document Detail


Effects of antihypertensive treatment on systolic blood pressure and renin in experimental hypertension in rats.
MedLine Citation:
PMID:  762665     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effects of pretreatment with hydralazine and alpha-methyldopa were assessed in rats made hypertensive by ligation of the left renal artery (LRA). Systolic blood pressure and peripheral renin activity (PRA) were measured 7 and 1 day before LRA and 2, 7 and 28 days after LRA. Systolic blood pressure increased 2 days after LRA in control and alpha-methyldopa-treated rats but not in the hydralazine-treated rats. Peripheral renin activity levels did not correlate with changes in systolic blood pressure. Peripheral renin activity first increased 7 days after LRA but decreased 28 days after LRA despite persistent hypertension in controls and alpha-methyldopa-treated rats. It is concluded that factors other than renin are involved in the initial and maintenance phases of this experimental model. In addition, hydralazine protects the rat with LRA from developing hypertension.
Authors:
J L Cangiano; C Rodríguez-Sargent; M Martínez-Maldonado
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of pharmacology and experimental therapeutics     Volume:  208     ISSN:  0022-3565     ISO Abbreviation:  J. Pharmacol. Exp. Ther.     Publication Date:  1979 Feb 
Date Detail:
Created Date:  1979-04-28     Completed Date:  1979-04-28     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0376362     Medline TA:  J Pharmacol Exp Ther     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  310-3     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Antihypertensive Agents / pharmacology*
Blood Pressure / drug effects*
Female
Hydralazine / pharmacology
Hypertension, Renal / physiopathology*
Hypertension, Renovascular / enzymology,  physiopathology*
Ligation
Methyldopa / pharmacology
Rats
Renin / blood*
Time Factors
Chemical
Reg. No./Substance:
0/Antihypertensive Agents; 555-30-6/Methyldopa; 86-54-4/Hydralazine; EC 3.4.23.15/Renin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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