Document Detail

Effects of antihypertensive therapy on left ventricular hypertrophy of essential hypertension: a role for insulin-like growth factor I?
MedLine Citation:
PMID:  8263889     Owner:  NLM     Status:  MEDLINE    
In a previous work we have found than an association exists between the presence of left ventricular hypertrophy (LVH) and increased circulating levels of insulin-like growth factor I (IGF-I) in essential hypertension. To address whether this association is of pathophysiological relevance the relationship between echocardiographically determined LVH and IGF-I levels was investigated in 49 patients with essential hypertension before and after one year of antihypertensive treatment with different regimens (nonpharmacological measures, bisoprolol, captopril). The control group consisted of 30 normotensive subjects without LVH. Before treatment IGF-I levels were higher (p < 0.05) in hypertensives with LVH, n = 17, (81.3 +/- 14.3 ng/ml) compared with hypertensives without LVH, n = 32, (57.4 +/- 3.9 ng/ml) and controls (61.3 +/- 3.9 ng/ml). A positive correlation was found between IGF-I levels and LVMI in the whole group of hypertensives (r = 0.32, p < 0.05). After one year of treatment hypertensives with initial LVH separated in two subgroups: those in which LVH regressed (n = 10) and those in which LVH persisted (n = 7). A similar diminution of BP was observed in the two subgroups of hypertensives. The IGF-I levels decreased significantly in patients in which LVH regressed (101.6 +/- 21.7 vs. 61.2 +/- 8.5 ng/ml; p < 0.05) and increased slightly in patients in which LVH persisted (51.2 +/- 8.9 vs. 68.5 +/- 7.9 ng/ml). Six patients in which LVH regressed showed a diminution of IGF-I after treatment. These six patients had received captopril as treatment.(ABSTRACT TRUNCATED AT 250 WORDS)
J Díez; C Laviades; G Mayor
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of human hypertension     Volume:  7     ISSN:  0950-9240     ISO Abbreviation:  J Hum Hypertens     Publication Date:  1993 Oct 
Date Detail:
Created Date:  1994-01-25     Completed Date:  1994-01-25     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8811625     Medline TA:  J Hum Hypertens     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  479-84     Citation Subset:  IM    
Department of Medicine, University of Zaragoza, Spain.
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MeSH Terms
Antihypertensive Agents / therapeutic use*
Bisoprolol / therapeutic use
Captopril / therapeutic use
Hypertension / complications*,  drug therapy*,  physiopathology
Hypertrophy, Left Ventricular / etiology*
Insulin-Like Growth Factor I / physiology*
Middle Aged
Regression Analysis
Reg. No./Substance:
0/Antihypertensive Agents; 62571-86-2/Captopril; 66722-44-9/Bisoprolol; 67763-96-6/Insulin-Like Growth Factor I

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