Document Detail

Effects of antihypertensive therapy on hypertensive vascular disease.
MedLine Citation:
PMID:  10981161     Owner:  NLM     Status:  MEDLINE    
Hypertension is associated with alterations in the structure, function, and mechanical properties of large and small arteries. Changes in the endothelium, smooth muscle cell, extracellular matrix, and possibly the adventitia, contribute to complications of hypertension. In large arteries, vascular hypertrophy is found, often with increased stiffness of media components. In small arteries, particularly in mild hypertension, rearrangement of smooth muscle cells around a smaller lumen without changes in media volume (eutrophic remodeling) occurs; in more severe hypertension, hypertrophic remodeling with increased vascular stiffness can be found. Vascular remodeling is accompanied by an increase in the extracellular matrix, particularly collagen deposition. Recent studies have demonstrated that vascular remodeling and endothelial dysfunction of small and large vessels may be normalized by treatment with some antihypertensive agents (angiotensin converting enzyme inhibitors, angiotensin AT(1) receptor antagonists, and long-acting calcium channel blockers). Angiotensin converting enzyme inhibitors have now been shown to improve outcomes in hypertensive patients, an effect that may in part be related to the vascular protective effects reviewed here.
J B Park; E L Schiffrin
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Current hypertension reports     Volume:  2     ISSN:  1522-6417     ISO Abbreviation:  Curr. Hypertens. Rep.     Publication Date:  2000 Jun 
Date Detail:
Created Date:  2000-10-13     Completed Date:  2000-10-13     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  100888982     Medline TA:  Curr Hypertens Rep     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  280-8     Citation Subset:  IM    
MRC Multidisciplinary Research Group on Hypertension, Clinical Research Institute of Montréal, 110 Pine Avenue West, Montréal, Québec, Canada H2W 1R7.
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MeSH Terms
Angiotensin I / antagonists & inhibitors
Angiotensin-Converting Enzyme Inhibitors / therapeutic use
Antihypertensive Agents / therapeutic use*
Arteries / drug effects
Arterioles / drug effects
Calcium Channel Blockers / therapeutic use
Collagen / drug effects
Elastic Tissue / drug effects
Endothelium, Vascular / drug effects
Extracellular Matrix / drug effects
Hypertension / drug therapy*
Muscle, Smooth, Vascular / drug effects
Protective Agents / therapeutic use
Receptors, Angiotensin / antagonists & inhibitors
Treatment Outcome
Vascular Diseases / drug therapy*
Reg. No./Substance:
0/Angiotensin-Converting Enzyme Inhibitors; 0/Antihypertensive Agents; 0/Calcium Channel Blockers; 0/Protective Agents; 0/Receptors, Angiotensin; 9007-34-5/Collagen; 9041-90-1/Angiotensin I

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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