| Effects of antihypertensive medication on hypertension in patients with sleep apnoea. | |
| | |
MedLine Citation:
|
PMID: 8061854 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The present study was to investigate the effect of four different antihypertensive medications [atenolol, hydrochlorothiazide (HCTZ), isradipine and spirapril] on the blood pressure and metabolic state of 18 patients with obstructive sleep apnoea. All patients received each of the drugs for a period of 8 weeks according to a randomized crossover design. Although all of the medications decreased systolic blood pressure (SBP), only spirapril decreased SBP significantly (17 +/- 15 mmHg; p < 0.001). All of the medications decreased diastolic blood pressure (DBP) significantly, but spirapril produced the greatest reduction (5-8 vs 10 mmHg, respectively). Both HCTZ and isradipine increased fasting serum total cholesterol concentration (0.3 +/- 0.5 and 0.3 +/- 0.4 mmol/l, respectively; p < 0.05). Atenolol decreased fasting serum high-density lipoprotein (HDL)-cholesterol concentration significantly (0.12 +/- 0.15 mmol/l; p < 0.01). Both HCTZ and isradipine increased fasting serum glucose concentration significantly (0.7 +/- 0.8 mmol/l and 0.6 +/- 0.7 mmol/l, respectively; p < 0.01). No significant effect on serum lipid and glucose levels was observed with spirapril. On the basis of these results, spirapril was the best medication for hypertensive patients with obstructive sleep apnoea. |
| | |
Authors:
|
L Pelttari; E Rauhala; I Kantola |
Related Documents
:
|
3355614 - Peripheral arterial disease in heterozygous familial hypercholesterolemia: no differenc... 19375714 - Sugar-sweetened beverages, serum uric acid, and blood pressure in adolescents. 2643864 - Effects of prazosin and labetalol on blood pressure control and blood lipid levels in p... 18301144 - Differences between diabetic and non-diabetic hypertensive patients with first acute no... 9310274 - Problems in the evaluation of antihypertensive therapy using the trough/peak ratio. 15665834 - Chronic inhibition of cyclic gmp phosphodiesterase 5a prevents and reverses cardiac hyp... |
Publication Detail:
|
Type: Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Blood pressure. Supplement Volume: 2 ISSN: 0803-8023 ISO Abbreviation: Blood Press Suppl Publication Date: 1994 |
Date Detail:
|
Created Date: 1994-09-22 Completed Date: 1994-09-22 Revised Date: 2008-02-26 |
Medline Journal Info:
|
Nlm Unique ID: 9300787 Medline TA: Blood Press Suppl Country: NORWAY |
Other Details:
|
Languages: eng Pagination: 88-91 Citation Subset: IM |
Affiliation:
|
Department of Medicine, Turku University Hospital, Finland. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Analysis of Variance Antihypertensive Agents / therapeutic use* Blood Pressure / drug effects, physiology Double-Blind Method Female Humans Hypertension / blood, complications, drug therapy* Male Middle Aged Sleep Apnea Syndromes / complications* |
| Chemical | |
Reg. No./Substance:
|
0/Antihypertensive Agents |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Placebo-controlled comparison of spirapril at 6, 12 and 24 mg/day in mild to severe essential hypert...
Next Document: Evidence of nuclear DNA fragmentation following hypoxia-ischemia in the infant rat brain, and transi...