Document Detail


Effects of an antihypertensive medication on functional capacity under simulated flight-typical stress-conditions.
MedLine Citation:
PMID:  10477504     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A model to investigate the functional capacity (psychomental performance) under stressful conditions was developed. Twenty eight patients with mild hypertension receiving Nitrendipine (20 mg) for 30 days were tested under hypoxic (16% oxygen) and/or orthostatic (-30 mmHg lower body negative pressure) conditions using a subset of the AGARD battery. The main effect was a decreasing performance of the grammatical reasoning task (GRT) under hypoxia or the combination of hypoxia and orthostasis. A simultaneous application of stressors while performing psychometric test batteries may be useful to reveal pharmaceutical influences on human performance and may help to recommend the use of drugs in occupational medicine.
Authors:
G Wolfram; C Drummer; R Helbig; C Hesse; R Klan; W D Sittner; F Baisch
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Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  European journal of medical research     Volume:  4     ISSN:  0949-2321     ISO Abbreviation:  Eur. J. Med. Res.     Publication Date:  1999 Sep 
Date Detail:
Created Date:  1999-11-04     Completed Date:  1999-11-04     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  9517857     Medline TA:  Eur J Med Res     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  379-81     Citation Subset:  IM; S    
Affiliation:
Institut für Flugmedizin der RWTH Aachen, Pauwelsstr. 30, 52057 Aachen, Germany. wolfram@pbmail.me.kp.dlr.de
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MeSH Terms
Descriptor/Qualifier:
Aerospace Medicine
Aircraft
Anoxia / physiopathology*
Antihypertensive Agents / administration & dosage*
Humans
Nitrendipine / administration & dosage*
Occupational Diseases / drug therapy*,  physiopathology
Posture
Psychometrics
Stress, Physiological / physiopathology*
Chemical
Reg. No./Substance:
0/Antihypertensive Agents; 39562-70-4/Nitrendipine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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