| Effects of an antihypertensive medication on functional capacity under simulated flight-typical stress-conditions. | |
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MedLine Citation:
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PMID: 10477504 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A model to investigate the functional capacity (psychomental performance) under stressful conditions was developed. Twenty eight patients with mild hypertension receiving Nitrendipine (20 mg) for 30 days were tested under hypoxic (16% oxygen) and/or orthostatic (-30 mmHg lower body negative pressure) conditions using a subset of the AGARD battery. The main effect was a decreasing performance of the grammatical reasoning task (GRT) under hypoxia or the combination of hypoxia and orthostasis. A simultaneous application of stressors while performing psychometric test batteries may be useful to reveal pharmaceutical influences on human performance and may help to recommend the use of drugs in occupational medicine. |
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Authors:
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G Wolfram; C Drummer; R Helbig; C Hesse; R Klan; W D Sittner; F Baisch |
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Publication Detail:
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Type: Clinical Trial; Journal Article |
Journal Detail:
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Title: European journal of medical research Volume: 4 ISSN: 0949-2321 ISO Abbreviation: Eur. J. Med. Res. Publication Date: 1999 Sep |
Date Detail:
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Created Date: 1999-11-04 Completed Date: 1999-11-04 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 9517857 Medline TA: Eur J Med Res Country: GERMANY |
Other Details:
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Languages: eng Pagination: 379-81 Citation Subset: IM; S |
Affiliation:
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Institut für Flugmedizin der RWTH Aachen, Pauwelsstr. 30, 52057 Aachen, Germany. wolfram@pbmail.me.kp.dlr.de |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aerospace Medicine Aircraft Anoxia / physiopathology* Antihypertensive Agents / administration & dosage* Humans Nitrendipine / administration & dosage* Occupational Diseases / drug therapy*, physiopathology Posture Psychometrics Stress, Physiological / physiopathology* |
| Chemical | |
Reg. No./Substance:
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0/Antihypertensive Agents; 39562-70-4/Nitrendipine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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